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叶酸与结直肠肿瘤

Folate and colorectal neoplasms
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摘要 流行病学和试验研究提示叶酸缺乏及叶酸代谢异常和结直肠肿瘤发病风险升高有关。亚甲基四氢叶酸还原酶(MTHFR)是调节叶酸代谢的关键酶,MTHFR C677T基因多态及饮酒影响叶酸代谢,从而影响结直肠肿瘤的发病风险。 A wealth of evidences consistently show inverse association of intake and/or blood level of folate with the incidence of colorectal neoplasms. Methylenetetrahydrofolate reductase（MTHFR） is a key regulatory enzyme in the metabolism of folate. MTHFR C677T gene polymorphisms and alcohol intake are associated with folate metabolism, then affect the incidence of colorectal neoplasms.
作者 耿欣燕 胡冰
机构地区 安徽医科大学附属省立医院化疗科
出处 《国际肿瘤学杂志》 CAS 2007年第12期935-938,共4页 Journal of International Oncology
关键词 叶酸 结直肠肿瘤 亚甲基四氢叶酸还原酶(NADPH) 饮酒 Folio acid Colorectal neoplasms Methylenetetrahydrofolate reductase （ NADPH2 ） Alcohol drinking
分类号 R735.3 [医药卫生—肿瘤]
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参考文献21

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国际肿瘤学杂志
2007年 第12期

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