摘要
目的了解高胆红素血症足月新生儿远期神经发育状况,探讨脑脊液神经元特异性烯醇化酶(CSF-NSE)水平对远期神经发育的预测价值。方法采用首都儿科研究所与心理研究所制定的0～4岁婴幼儿精神发育量表对足月高胆红素血症及健康新生儿各39例进行3、24个月的智力发育随访;39例高胆红素血症足月新生儿在黄疸极期检测CSF-NSE水平。结果随访3、24个月均发现高胆红素血症足月新生儿总发育商(DQ)低于对照组,差异有统计学意义(P=0,0.047);单项DQ比较显示精细动作和社交行为均明显低于对照组(Pa=0);3、24个月DQ与CSF-NSE水平存在显著负相关(r=-0.46P=0.04;r=-0.32P=0.047),与TSB水平无明显关系(r=-0.21P=0.20;r=-0.30P=0.06)。结论高胆红素血症可能对远期智力发育有影响,CSF-NSE可作为判断高胆红素血症新生儿远期神经发育的预测因子之一。
Objective To study the long - term neurodevelopment in term neonates with hyperbilirubinemia and explore the predictive value of cerebrospinal fluid neuron specific enolase （ CSF - NSE） on long - term neurodevelopment outcome. Methods A mental and psychomotor scale for 0 -4 years old was performed to evaluate the intelligence development of 39 neonates with hyperbilirubinemia and 39 randomly selected healthy controls when they were at 3 to 24 months old. The former were tested for the level of CSF - NSE in jaundice climax. Results There was significant difference between 2 groups in total development quotient （DQ） tested at 3 month and 24 month old （P = 0, 0.047 ）. It was shown that the DQ scores for fine activity and social behavior were significantly lower in the study group than those in the control group （Pa =0）. Furthermore, within the hyperbilirubinemia group, CSF -NSE was significantly associated with DQ of 3 month and 24 month old, while there was not association with TSB. The correlation coefficients were - 0.46 （ P = 0. 04 ） and - 0. 32 （ P = 0.047 ） , respectively, Conclusions Hyperbilirubinemia may influence long - term neurodevelopment of term infants and CSF - NSE can predict this outcome.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2007年第24期1867-1868,共2页
Journal of Applied Clinical Pediatrics
基金
广东省医学科研基金项目资助(A2002845)
