摘要
目的:总结遗传性非息肉病性结直肠癌(HNPCC)家系的临床特点,提高临床诊断和治疗水平。方法:收集7个HNPCC家系的病例资料,分析其发病特点并记录随访结果。结果:7个HNPCC家系共有癌症患者23例,肿瘤灶27处:大肠外瘤灶3处;大肠瘤灶24处,其中有13处位于脾曲近侧结肠,占54.1%。平均发病年龄为41.2岁,17例(73.5%)发病在50岁以前。1家系累及连续三代人、4家系累及连续两代人。多原发癌患者4例,其中3例为肠外癌。结论:HNPCC具有发病年龄轻、垂直传递、肠外癌发病率高、常见多原发癌、好发于右半结肠、病理分化较差的特点,但预后相对较好。
Objective： To study the clinical characteristics of hereditary nonpolyposis colorectal cancer（HNPCC） so as to evaluate the diagnosis and treatment of this disease. Methods： Twenty three patients from 7 HNPCC families were analyzed. Results：All 23 patients and 27 malignant neoplasms were found in 7 HS/PCC families, among which 3 were extracolonic cancers, while 24 were colonic cancers. Cancers located proximal to the splenic flexure account- ing for 54.1%. The median age of confirmed diagnosis was 41.2 years. 1 familie transmitted vertically to 3 generations, while 4 families 2 generations. There were 4 multiple colorectal cancer patients. Conclusion ： HNPCC patients had the characteristics of early onsetting, high incidences of extra colrectal cancer, poor differentiation, frequent multiple colorectal cancers and the predominance of right - sided colorectal cancers. But HNPCC has a better progno- sis comparing with common colorectal cancer.
出处
《现代肿瘤医学》
CAS
2007年第5期670-671,共2页
Journal of Modern Oncology
关键词
结直肠肿瘤
遗传性非息肉病性
诊断
治疗
colorectal tumor
hereditary nonpolyposis colorectal cancer
diagnosis
treatment
