摘要
目的:通过检测垂体肿瘤转化基因(pituitary tumor transforming gene,PTTG)和碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)在非霍奇金淋巴瘤(NHL)中的表达,研究它们的表达与NHL临床病理指标的联系。方法:应用原位杂交法和免疫组化法检测50例NHL患者和20例良性淋巴结炎组织中PTT-GmRNA和bFGF蛋白的表达。结果:NHL中PTTGmRNA和bFGF蛋白在NHL中的阳性表达率分别为54.0%和50.0%,其阳性表达率及表达分级均高于对照组。PTTGmRNA和bFGF蛋白均与NHL的恶性程度及临床分期正相关。PTTGmRNA与bFGF蛋白表达正相关。结论:NHL中PTTG高表达。PTTG可能通过直接和/或间接方式促进bFGF表达参与NHL的发生、发展。
Objective：To study the expression of pituitary tumor transforming gene（PTTG） and basic fibroblast growth factor（bFGF） in non -Hodgkin＇s lymphoma（NHL） and explore the correlation among their overexpression and clinicopathological parameters of NHL. Methods ： Fifty cases of NHL and 20 cases of benign lymphademopathy were studied. PTTG expression was measured at mRNA level by in site hybridization; bFGF expression was measured at protein level by immunohistochemistry. Results：Positive expression rate of PTTGmRNA and bFGF protein were 54.0% and 50.0% , respectively. Both positive expression rate and expression grade of PTTGmRNA and bFGF protein were significantly higher in NHL than those in benign lymphademopathy. Both expression of PTTGmRNA and bFGF protein were positively related to NHL histopathologic grade and clinical stage, respectively. Expression of PTTGmRNA was positively related to the expression of bFGF protein. Conclusion： There was overexpression of PTTG in NHL. Maybe PTTG played important role in the formation and development of NHL by means of increasing expression of bFGF directly or indirectly.
出处
《现代肿瘤医学》
CAS
2007年第12期1838-1841,共4页
Journal of Modern Oncology
