摘要
目的研究2型糖尿病患者脂蛋白各亚组份与颈动脉内膜中层厚度的关系。方法采用超速离心及高效液相色谱法测定55例2型糖尿病患者的血清脂蛋白亚组份,根据超声检测颈动脉内膜中层厚度分为有、无病变组,分析其与脂蛋白亚组份之间的关系。结果(1)有病变组的年龄高于无病变组(P<0.05)。(2)有病变组脂蛋白(a)水平高于无病变组。其余脂蛋白及其亚型组间差异无统计学意义。(3)调整年龄、性别、体质指数后,颈动脉内膜中层增厚分别与脂蛋白(a)和B型低密度脂蛋白呈正相关;脂蛋白(a)与低密度脂蛋白呈正相关;甘油三酯分别与空腹血糖、B型低密度脂蛋白呈正相关,与高密度脂蛋白、高密度脂蛋白2和A型低密度脂蛋白呈负相关(P<0.05)。以有病变、无病变为因变量进行多因素Logistic回归分析发现,年龄、脂蛋白(a)水平升高是2型糖尿病患者颈动脉内膜中层增厚的独立危险因素(P<0.001和P=0.021)。结论脂蛋白(a)可能是2型糖尿病患者早期动脉粥样硬化的危险预测指标。
Aim To investigate the association of lipoproteins subfraetions with intimal medial thickness （ IMT） of carotid artery in type 2 diabetic patients. Methods The subfi：actions of lipoproteins were determined by ultracentrifugation and high-performance liquid chromatiography, and the IMT of both sides carotid artery were measured by B-mode ultrasonngraphy in 55 type 2 diabetic patients, divided into two groups by the IMT 〉 1.2 mm （ n = 20） and ≤ 1.2 mm （ n = 35）. The relationship between the lipeprotein subfractiom and IMT was investigated. Result The older age was more common in patients with IMT 〉 1.2 mm compared to those with IMT≤1.2 mm （ P 〈 0.05）. The serum level of lipeprotein （a） was higher in group IMT 〉 1.2mm（0.122±0.077mmol/L vs 0.081±0.049mmol/L, P〈0.05）. After adjusting the age, sexandBMI, thehigher IMT was positively correlated with Lp （a） and LDLb; Lp（a） was positively correlated with LDL; TG was positively correlated with fasting blood glucose and LDLb, inverse correlated with HDL, HDL2 and LDLa （ P 〈 0.05 ）. With stepwise multivariate logistic regression analysis, older age and Lp（a） were identified as significant and independent risk factors for higher IMT of carotid artery in type2 diabetic patients （ P 〈 0.001 and P=0.021 respectively）. Conclusion The results suggest flint Lp（a） has a strong association with IMT of carotid arteries and might he the important predictor for early athemsclerosis in type 2 diabetic patients.
出处
《中国动脉硬化杂志》
CAS
CSCD
2007年第8期634-637,共4页
Chinese Journal of Arteriosclerosis
