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妊娠期糖尿病的发病机制 被引量：15

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摘要 妊娠期糖尿病(GDM)指妊娠前无糖尿病和糖耐量异常,在妊娠期发生或首次发现的糖尿病或糖耐量异常。它由多种因素作用引起,胰岛素抵抗(IR)和胰岛B细胞分泌降低是GDM发病机制的重要环节。其中遗传、胰岛素信号系统障碍、胎盘激素、脂肪细胞因子、炎症反应因子、浆细胞膜糖蛋白(PC-1)等参与IR机制,IR增强、胰岛B细胞储备低、胰岛淀粉样多肽的促凋亡等导致胰岛B细胞分泌降低。此外,遗传易感性、慢性炎症、氧化应激、吸烟史、不良孕产史和孕妇体重、年龄等危险因素也参与了GDM的发病。
作者 苏会璇 钟宇华
机构地区 广西医科大学第九附属医院内分泌科
出处 《现代妇产科进展》 CSCD 北大核心 2007年第9期703-706,共4页 Progress in Obstetrics and Gynecology
关键词 糖尿病 妊娠期 发病机制 综述文献
分类号 R714.256 [医药卫生—妇产科学]
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参考文献20

  • 1Kopp W. Role of High-insulinogenic nutrition in the etiology of gestational diabetes mellitus [ J ]. Med Hgpotheses, 2005,64 : 101-103
  • 2Megia A, Gallart L, Fernandez-Real J M, et al. Mannosebinding lectin gene polymorphisms are associated with gestational diabetes mellitus [ J ]. J Clin Endocrinol Metab, 2004,89 : 5081-5087
  • 3弋花妮,李娟,白晶,孙茜,彭婷.妊娠期糖尿病与胰岛素抵抗[J].中国妇幼健康研究,2006,17(3):181-184. 被引量：14
  • 4Kirwan JP, Hauguel-De Mouzon S, Lepercq J, et al. TNF - alpha is a predictor of insulin resistance in human pregnancy [ J ]. Diabetes,2002,51:2207-2213
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二级参考文献30

  • 1Kuhl C. Etilolgy and pathogenesis of gestational diabetes. Diabet Care,1998,21:19-26.
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  • 4Olerup O, Zetterguist H. HLA-DR typing by PCR-amplification with sequence-specific primers in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaberic transplantation. Tissue Antigen, 1992, 39:225-235.
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共引文献33

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引证文献15

二级引证文献67

现代妇产科进展
2007年 第9期

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