摘要
目的:探讨抗细胞黏附分子-1(ICAM-1)单克隆抗体对子痫前期的治疗作用和安全性。方法:孕鼠50只,10只为正常组(A组),另40只利用内毒素制作大鼠子痫前期模型,其中20只为ICAM-1单抗治疗组(B组),另20只为对照组(C组),观察各组孕鼠血压、尿蛋白、肝肾功能、仔鼠及胎盘重量的变化。结果:ICAM-1单抗治疗组血压及尿蛋白均明显低于对照组(P<0.01)。治疗组和对照组谷丙转氨酶与正常组相比均无显著差异,尿素氮、肌酐及尿酸治疗组与正常组差异无显著性(P>0.05),对照组则高于正常组(P<0.01)。各组间胎仔数无显著差异;治疗组及对照组死胎率明显高于正常组(P<0.05),但两组之间无显著差异;治疗组仔鼠身长、体重及胎盘重量与正常组无显著差异(P>0.05),对照组则明显降低(P<0.01)。结论:ICAM-1单克隆抗体不仅对子痫前期有明显的治疗效果,而且不损害肝、肾功能,对胎儿无明显毒副作用。此结果可能为子痫前期的预防和治疗提供一个新的思路。
Objective：To evaluate the effectiveness and safety of monoclonal antibody to ICAM-1 treatment with preeclampsia in rats. Methods：Fifty pregnant rats were divided into normal group （n = 10）, treated group（ n = 20） and no treated group（ n = 20）. The rat model for preeclampsia were induced by endotoxin infusion in pregnant rat, and were treated with mono- clonal antibody to ICAM-1. Blood pressure, albuminuria, ALT, BUN, CRE, UA, fetal rats status and weight of placentas were monitored for every groups. Results： Blood pressure and albuminuria in treated group were significantly lower than those in no treated group （ P 〈 0.01 ）. ALT in treated group and in no treated group has not significantly difference than that in normal group. BUN, CRE and UA in treated group and in no treated group were higher than those in normal group, but there were not significantly difference between treated group and normal group （ P 〉 0.05 ） while significantly difference were found between no treated group and normal group （P 〈0. O1 ）. The litter sizes had no significant deviation in every groups. Still birth rate of treated group or of no treated group was significantly higher than that of normal group, but there was no significantly deviation between preceding two groups. Fetal rats status and weight of placentas had no significantly difference between the treated group and normal group（ P 〉 0.05 ）, but sig- nificantly lower in no treated group （ P 〈 0.01 ）. Conclusion： Monoclonal antibody to ICAM-1 have apparent therapeutic efficacy to preeclampsia and have no visible harmful effect to liver, kidney or fetus in rats.
出处
《现代妇产科进展》
CSCD
北大核心
2007年第9期661-663,666,共4页
Progress in Obstetrics and Gynecology
基金
广东省医学科学技术研究基金资助项目(No:A2002376)
