摘要
目的探讨哮喘患儿外周血一氧化氮（NO）、可溶性白细胞介素2受体（SIL-ZR）及IgE的变化。方法支气管哮喘急性发作期患者44例，男23例，女21例，对照组为15例健康儿童，男9例，女6例。分别在哮喘急性发作期和缓解期采静脉血，测定NO、SIL-ZR和IgE，并与对照组进行比较。结果支气管哮喘息性发作期患者与缓解期患者（30例）皿中NO分别为107.99±24.96μmol／L和81.36±14.31μmol／L（P＜0.001）;SIL-ZR分别为259.55±58.82kU／L和213.23±33.72kU／L（P＜0.001）;IgE分别为932.61±637.23kU／L和760.80±53644kU／L（P＞0.05）。对照组血中NO为82.26±14.21，与急性发作期哮喘息者相比，有显著性差异（P＜0.001）。结论支气管哮喘急性发作期患儿血中NO和SIL-2R均明显高于缓解期患者和健康儿童。内源性NO在哮喘的发病中可能发挥着重要作用。
Objectives: To search for the changes of nitric oxide(NO). soluble interleukin-2 receptor (SIL-2R) and IgE in Peripheral blood of child patients with asthma.Methods: There were 44 child patients with bronchial asthma in acute attack, 23 males and 2l femalcs. There wcre 15 healthy children (9 males and 6 females)in control group. The vcnous blood of the patients in acute attack and restoration stage was drawn and the NO.SIL-2R and IgE werc determined. The deterndnation results were compared with the control group.Results:The determination results of the asthma patients in acute attack and restoration stage (30 cases) were as follows: NO: 107. 99± 24. 96ymol/L and 81. 36±14. 31μmol/L (P<0.001); STL-2R: 259. 55 ± 58. 82 kU/L and 213. 23± 33. 72kU/L (P<0.05):IgE: 932.61±637. 23 kU/L and 760. 80±536.44 kU/L, (P>0.05). The level of NO of the patients in control group was 82. 26±14. 21μmol/L, there was an obvious difference (P<0. 001) compared with the asthrna patients in acute attack stage.Conclusions: The leve1s of NO and SIL-2R of the child patients with hronchial asthma in acute attack stage are obviously higher than that with bronchial asthma in restotation stage and in control group. The endogenous NO may play an important role in asthma attack.
出处
《实用儿科临床杂志》
CAS
CSCD
1997年第3期151-153,共3页
Journal of Applied Clinical Pediatrics
关键词
一氧化氮
白细胞介素2
哮喘
IGE
儿童
nitric oxide
soluble interleukin-2 receptor
immunoglobulin E
