摘要
目的研究葡萄籽提取物对人体抗氧化能力的影响。方法选年龄在45～65岁的健康志愿者100人，根据血清超氧化物歧化酶（superoxide dismutase，SOD）、谷胱甘肽过氧化物酶（glutathione peroxidase，GSH．Px）活性和丙二醛（maleic dialdehyde，MDA）含量，随机分为试食组和对照组，每组50人，试食组受试者每天口服葡萄籽提取物软胶囊1g，连续用3个月，对照组不服药。试验前后每人测一次血清中SOD、GSH-Px、MDA三项指标。结果试验后试食组血清SOD、GSH．PX显著高于对照组（P均〈0．05），试食组血清MDA含量显著低于对照组（P〈0．01）；且试食组试验前后自身比较三项指标亦有统计学差异（P均〈0．01）。结论葡萄籽提取物具有明显的体内抗氧化活性。
Objective To study the anti-oxidative effect of grape seed extract （GSE） in the human body. Methods One hundred healthy volunteers aged from 45 to 65 were randomly divided into two groups： the control group and the GSE-treated group based on the SOD, GSH-Px and MDA levels in the serum. The GSE capsule was administered to the GSE-treated group 1 g/d orally for 3 months, while no drugs were administered to the control group. The SOD, GSH-Px and MDA levels in the serum were determined both prior to and after the experiment. Results The SOD and GSH-Px levels were significant higher in the GSE-treated group than in the control group （ P 〈 0.05）, while the MDA level was significantly lower in the GSE-treated group than in the control group （ P 〈 0.01 ）. Moreover, there were significant differences in the three indexes in the GSE-treated group between prior to and after the experiment （P 〈 0.01 ）. Conclusion GSE has a significant anti-oxidative effect in vivo.
出处
《山东大学学报（医学版）》
CAS
北大核心
2007年第10期985-987,共3页
Journal of Shandong University:Health Sciences
关键词
葡萄籽提取物
原花青素
抗氧化
Grape seed extract
Proanthocyanidin
Antioxidant
