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动脉粥样硬化药物治疗的新靶点——核受体Nur77和类视黄醇X受体 被引量：2

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摘要 核受体（nuclear receptor，NR）是一类在生物体内广泛分布、配体依赖的转录因子，其成员众多，构成了一个大家族，可分为4大类：类固醇激素受体、甲状腺激素和维生素D受体、孤儿核受体（orphan nuclear receptors，ONR）及可被代谢中间产物激活的受体。NR与相应的配体及其辅调节因子相互作用，调控基因的协调表达，从而在机体的生长发育、新陈代谢、细胞分化和凋亡、免疫反应及体内许多生理过程中发挥重要作用。
作者 张晓坤 沈玲红 何奔
机构地区 加利福尼亚Burnham医学研究院 上海交通大学医学院附属仁济医院心内科
出处 《内科理论与实践》 2007年第5期292-294,共3页 Journal of Internal Medicine Concepts & Practice
基金 国家自然科学基金资助项目(项目编号:30670880和30600242)
关键词 核受体 类视黄醇X受体 核受体Nur77 动脉粥样硬化
分类号 R543.2 [医药卫生—心血管疾病]
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参考文献10

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同被引文献34

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内科理论与实践
2007年 第5期

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