摘要
目的观察毒淋清冲剂治疗慢性淋病的疗效及治疗前后前列腺液中肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)的变化,以探讨中医药治疗慢性淋病的疗效及机理。方法将慢性淋病患者随机分为治疗组(口服毒淋清冲剂)、对照组(静脉推注头孢三嗪),观察两组治疗前后的临床症状、体征改变和NIH-CPSI症状指数评分,并采用双抗夹心法(ELISA)检测治疗前后前列腺液中TNF-α、IL-2的含量。结果治疗组的治愈率与对照组相比无统计学意义,但NIH-CPSI症状评分具有统计学意义;治疗后两组TNF-α均显著降低,与治疗前相比均有统计学意义(P<0.01);治疗后两组TNF-α相比无统计学意义(P>0.05)。治疗组治疗后IL-2升高,与治疗前相比有统计学意义(P<0.05),而对照组治疗后IL-2下降,与治疗前相比,无统计学意义(P>0.05)。结论毒淋清冲剂是治疗慢性淋病的有效药物,并具有免疫调节作用。
Objective To observe the curative effect of DuLinOing dissolved medicines on treatment of chronic gonorrhea and to investigate its influence on changes of TNF- α and IL-2 in EPS. Methods The clinical symptoms, physical signs, NIH-CPSI scores and the concentrations of TNF- α and IL-2 in EPS in control group （prior and posttreatment with Ceftriaxone only） and experiment group （prior and post-treatment with DuLinOing only） were compared. Results Compared with the control group, the treatment group had no advantage in terms of the cute rate; but the NIH-CPSI scores was significantly higher in DuLinOing treatment group （P〈0.05）. The concentration of TNF- α in both groups decreased obviously （P〈0.01）. The concentration of IL-2 in DuLinOing treatment group increased compared with pre-therapy （P〈0.05）; On the contrary, the concentration of IL-2 in control group slightly decreased in comparison to pre-therapy （P〉0.05）. Conclusion DuLinOing dissolved medicines are effective for chronic gonorrhea treatment and have equivalent antibacterial effect of Ceftriaxone. There is also immuno-regulatory effects.
出处
《中国男科学杂志》
CAS
CSCD
2007年第8期53-56,共4页
Chinese Journal of Andrology
基金
广东省中医药管理局资助课题(立项编号:099633)
关键词
毒淋清冲剂
淋病
肿瘤坏死因子α
白细胞介素2
DuLinQing dissolved medicines
gonorrhea
tumor necrosis factor-alpha（TNF- α）
Interleukin（IL-2）
