摘要
目的:观察奥氮平合并氯硝西泮治疗精神分裂症急性精神运动性兴奋的疗效与不良反应。方法:65例精神分裂症急性期兴奋患者,随机分为口服奥氮平合并肌内注射氯硝西泮组(奥氮平组)34例和肌内注射氟哌啶醇组(氟哌啶醇组)31例治疗,疗程7 d。以阳性与阴性症状量表兴奋激越项目(PANSS-EC)和治疗中出现的症状量表(TESS)评定疗效和不良反应。结果:奥氮平组与氟哌啶醇组疗效相当,差异无显著性(P>0.05)。两组急性兴奋症状均获明显改善,氟哌啶醇组不良反应发生率高于奥氮平组(P<0.05)。结论:奥氮平合并氯硝西泮可有效治疗精神分裂症患者急性期精神运动性兴奋,疗效与氟哌啶醇相当,不良反应明显少于氟哌啶醇。
Objective：To evaluate the efficacy and side effects of olanzapine combine with clonazepam in the treatment of schizophrenia with acute psychomotor excitation. Method： Sixty-five schizophrenics with acute excitation were randomly divided into two groups, the olanzapine group （ n = 34） were given oral olanzapine and intrmnuscular injection of clonazepam, while the haloperidol gToup （ n = 31） were received intrmnuscular injection of haloperidol for seven days. All the patients were assessed with positive and negative symptom scale （PANSS-EC）and treatment emergent symptom scale （TESS）. Results：The symptoms of acute psychomotor excitation improved significantly in both groups, but no significant differences in the efficacy between two groups （P 〉 0.05）. The incidence of side effects in haloperidol group was higher than that in olanzapine group （ P 〈 0.05）. Conclusion：Olazapine combine with clonazepam has good efficacy and few side effects in the treatment of schizophrenia with acute psychomotor exication.
出处
《临床精神医学杂志》
2007年第4期239-240,共2页
Journal of Clinical Psychiatry
