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Her-2/neu、p53和P-gp在非小细胞肺癌中的表达 被引量：2

Expressions of Her-2/neu,p53 and P-gp in Non-small Cell Lung Cancer
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摘要 [目的]探讨非小细胞肺癌(NSCLC)中Her-2/neu、p53和P-gp的表达及临床意义。[方法]采用免疫组化EnVision法,对60例NSCLC及其20例正常肺组织中Her-2/neu、p53和P-gp进行检测。[结果]Her-2/neu、p53和P-gp相关蛋白在NSCLC中的表达分别是75%、70%和75%,而正常组织未见表达(P均<0.01)。Her-2/neu的表达与病理类型和组织学分级呈相关性(P=0.031和P=0.047);p53的表达与淋巴结转移、临床分期有关(P=0.024和P=0.003);P-gp的表达与病理类型有关(P=0.020);三者之间,Her-2/neu的阳性表达与p53和P-gp的阳性表达存在明显正相关性(P=0.025和P=0.000),而p53的阳性表达与P-gp的阳性表达之间未见明显相关性(P=0.517)。[结论]Her-2/neu、p53和P-gp在NSCLC的发展过程中起了重要作用,联合检测该三项基因的表达将有助于判断是否存在肿瘤的原发耐药及治疗方案的选择。
作者 周宝宁 束永前 黄文斌 王劲松 肖健 田韧 曹秀峰
机构地区 南京医科大学附属南京第一医院
出处 《肿瘤学杂志》 CAS 2007年第4期287-289,共3页 Journal of Chinese Oncology
关键词 癌 非小细胞肺 HER-2/NEU P53 P-GP 免疫组化
分类号 R734.2 [医药卫生—肿瘤]
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参考文献10

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同被引文献14

  • 1章雪林,薛松,郑家豪,刘沙.非小细胞肺癌中骨桥蛋白和P21的相关性研究[J].中国肺癌杂志,2007,10(4):288-290. 被引量：4
  • 2Xin-yun Wang,Zhi Yao,Yan Li,Ting Liu,Hai-yan Zheng,Cong-zhong Zhu,Cui-yun Sun,Ai-xiang Wang,Min Zhao,Xing-ye Wu.EXPRESSION AND SIGNIFICANCE OF SURVIVIN mRNA IN LUNG CANCER TISSUE MICROARRAY DETECTED BY FISH[J].Chinese Medical Sciences Journal,2005,20(3):214-216. 被引量：7
  • 3李作生,李保庆.p21和p27基因多态性与肿瘤的相关性[J].国际遗传学杂志,2006,29(4):317-320. 被引量：23
  • 4Ornella Cazzalini,Paola Perucca,Federica Valsecchi,Lucia A. Stivala,Livia Bianchi,Vanio Vannini,Ennio Prosperi.Intracellular localization of the cyclin-dependent kinase inhibitor p21CDKN1A-GFP fusion protein during cell cycle arrest[J]. Histochemistry and Cell Biology . 2004 (5)
  • 5A. A. Morgunkova,V. P. Almazov,S. M. Strunina,B. P. Kopnin,P. M. Chumakov.Dominant-Negative Inactivation of p53: The Effect of the Proportion between a Trans-Dominant Inhibitor and Its Target[J]. Molecular Biology . 2003 (1)
  • 6Pimlak Charoenkwan,Christof Senger,Sheila Weitzman,Elizabeth Sexsmith,Christopher G. Sherman,David Malkin,Paul S. Thorner.Significance of p53 Expression in Immature Teratomas[J]. Pediatric and Developmental Pathology . 2002 (5)
  • 7Prenzel N,Fischer O M,Streit S,et al.The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocrine Related Cancer . 2001
  • 8Schneider P M,Praeuer H W,Stoeltzing O,et al.Multiple molecular marker testing (p53,C-Ki-ras,c-erbB-2) improves estimation of prognosis in potentially curative resected non-small cell lung cancer. British Journal of Cancer . 2000
  • 9Meert A P,Martin B,Paesmans M,et al.The role of HER-2/neu expression on the survival of patients with lung cancer: a systematic review of the literature. British Journal of Cancer . 2003
  • 10李向荣,林星余,肖忠秀,蒋海霞,唐琼兰,刘馨.p21结构功能与研究新进展[J].医学综述,2008,14(14):2094-2097. 被引量：25

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肿瘤学杂志
2007年 第4期

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