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ω-3多不饱和脂肪酸的免疫调节作用及其在器官移植中的应用 被引量：1

Immunoregulatory Effects of ω-3 Polyunsaturated Fatty Acid and Its Applications in Organ Transplantation
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摘要 目的介绍免疫营养素ω-3多不饱和脂肪酸(ω-3PUFA)在调节免疫功能方面的作用及目前在器官移植领域的应用情况。方法复习近几年的相关文献并进行综述。结果ω-3PUFA具有免疫调控作用,可抑制T细胞、B细胞等免疫活性细胞的活化、增殖,抑制细胞因子的产生,调节免疫应答;能改善移植器官功能,延长存活时间,减少排斥反应,减轻免疫抑制剂副作用。结论ω-3PUFA的免疫调控作用在器官移植领域可望有广阔应用前景,但仍需深入研究。 Objective To investigate the immunoregulatory effects of immunonutrient ω-3 polyunsaturated fatty acid （PUFA） and its applications in organ transplantation. Methods Relevant literatures of recent years were reviewed. Results The immunoregulatory effects of ω-3 PUFA can inhibit proliferation and activation of the immunocompetent cells including T cell and B cell, reduce cytokine production, modulate immunologic response, improve graft function, pro-long survival, reduce episodes of rejection, and lessen adverse reactions of immunosuppressor. Conclusion ω-3 PUFA should have wide applications in organ transplantation due to its immunoregulatory effects. However, this research should be further studied.
作者 张鸣 李波
机构地区 四川大学华西医院肝脏移植中心
出处 《中国普外基础与临床杂志》 CAS 2007年第4期497-501,共5页 Chinese Journal of Bases and Clinics In General Surgery
关键词 Ω-3脂肪酸 免疫调控 器官移植 ω-3 fatty acid Immunoregulation Organ transplantation
分类号 R392.4 [医药卫生—免疫学]
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参考文献43

  • 1Simopoulos AP.Omega-3 fatty acids in inflammation and autoimmune diseases[J].J Am Coll Nutr,2002; 21(6):495
  • 2Bennett WM,Carpenter CB,Shapiro ME,et al.Delayed omega-3 fatty acid supplements in renal transplantation.A double-blind,placebo-controlled study[J].Transplantation,1995; 59(3):352
  • 3Maachi K,Berthoux P,Burgard G,et al.Results of a 1-year randomized controlled trial with omega-3 fatty acid fish oil in renal transplantation under triple immunosuppressive therapy[J].Transplant Proc,1995; 27(1):846
  • 4Calder PC.Can n-3 polyunsaturated fatty acids be used as immunomodulatory agents?[J].Biochem Soc Trans,1996; 24(1):211
  • 5Vandenbroecke C,Caillat-Zucman S,Legendre C,et al.Differential in situ expression of cytokines in renal allograft rejection[J].Transplantation,1991; 51(3):602
  • 6Calder PC.Effects of fatty acids and dietary lipida on cells of the immune system[J].Proc Nutr Soc,1996; 55(1B):127
  • 7Watson J,Madhok R,Wijelath E,et al.Mechanism of action of polyunsaturated fatty acids in rheumatoid arthritis[J].Biochem Soc Trans,1990; 18(2):284
  • 8Furst P,Kuhn KS.Fish oil emulsions:what benefits can they bring?[J].Clin Nutr,2000; 19(1):7
  • 9Yaqoob P,Newsholme E,Calder PC.The effect of dietary lipid manipulation on rat lymphocyte subsets and proliferation[J].Immunology,1994; 82(4):603
  • 10Thies F,Nebe-von-caron G,Powell JR,et al.Dietary supplementation with eicosapentaenoic acid,but not with other long-chain n-3 or n-6 polyunsaturated fatty acids,decreases natural killer cell activity in healthy subjects aged ＞55 y[J].Am J Clin Nutr,2001; 73(4):539

二级参考文献19

  • 1Ha YL, Grimm NK, Pariza MW. [J]. Carcinogenesis, 1987, 8: 1881-1887.
  • 2Sebedio JL, Gnaedig S, Chantigny JM. [J]. Curt Opin Clin Nutr Metab Care, 1999,2:499-506.
  • 3Parodi PW.[J].J Dairy Sci,1999,82(6) :1339-1349.
  • 4Sugano M,Tsujita A,Yamasaki M,et al. [J]. Lipids 1998,33(5) :521-527.
  • 5Chew BP, Wong TS, Shultz TD, et al. [J]. Anticancer Res, 1997, 17(2A) : 1099-1106.
  • 6Wong MW, Chew BP, Wong TS, et al. [J]. Anticancer Res, 1997, 17( 2A ) : 987-993.
  • 7Hayek MG,Han SN,Wu D,et al. [J].J Nutr,1999,129(1) :32-38.
  • 8Bassaganya-Riera J,Hontecillas R,Zimmerman DR,et al. [J] .J Nutr,2001,131 (9) :2370-2377.
  • 9Bassaganya-Riera J, Hontecillac-Magarzo R, Bregendahl K. et al. [ J ]. J Anim Sci,2001,79(3) :714-721.
  • 10Bassaganya-Riera J, Hontecillas R,Zimmerman DR, et al. [J]. Vaccine,2002,20(9-10) : 1435-1444.

共引文献5

同被引文献21

  • 1马正伟,刘利东,李昆,张玉君,陈利均,董家鸿.肝移植大鼠肠外营养模型的建立与评价[J].第三军医大学学报,2004,26(22):2054-2056. 被引量：2
  • 2夏延平,苏宜香.n-3多不饱和脂肪酸影响炎症及免疫分子机制研究进展[J].现代免疫学,2004,24(6):517-519. 被引量：27
  • 3王琳,窦科峰.T淋巴细胞与肝移植免疫[J].国外医学（外科学分册）,2005,32(5):339-342. 被引量：5
  • 4Alexander JW.Role of immunonutrition in reducing complications following organ transplantation.Transplant Proc 2000; 32:574-575
  • 5Kamada N,Calne RY.A surgical experience with five hundred thirty liver transplants in the rat.Surgery 1983; 93:64-69
  • 6Banff schema for grading liver allograft rejection:an international consensus document.Hepatology 1997;25:658-663
  • 7Boleslawski E,Conti F,Sanquer S,Podevin P,Chouzenoux S,Batteux F,Houssin D,Weill B,Calmus Y.Defective inhibition of peripheral CD8+T cell IL-2 production by anti-calcineurin drugs during acute liver allograft rejection.Transplantation 2004; 77:1815-1820
  • 8Wang YL,Tang ZQ,Gao W,Jiang Y,Zhang XH,Peng L.Influence of Th1,Th2,and Th3 cytokines during the early phase after liver transplantation.Transplant Proc 2003; 35:3024-3025
  • 9He XY,Chen J,Verma N,Plain K,Tran G,Hall BM.Treatment with interleukin-4 prolongs allogeneic neonatal heart graft survival by inducing T helper 2responses.Transplantation 1998; 65:1145-1152
  • 10Tashiro H,Shinozaki K,Yahata H,Hayamizu K,Okimoto T,Tanji H,Fudaba Y,Yamamoto H,FanX,Ito H,Asahara T.Prolongation of liver allograft survival after interleukin-10 gene transduction 24-48 hours before donation.Transplantation 2000;70:336-339

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中国普外基础与临床杂志
2007年 第4期

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