摘要
目的研究普伐他汀用于单纯收缩期高血压(ISH)治疗的疗效。方法选取ISH患者72例,随机分为对照组和治疗组。两组均常规应用降压药物,治疗组于此基础上加用普伐他汀钠20mg,每晚1次。分析两组患者治疗前、后血压和脉压(PP)变化及心、脑血管事件发生率,两组随访时间均为1年。结果治疗后治疗组收缩压及脉压与对照组比较有显著差异(P<0.01),治疗组脉压下降平均达18mmHg,对照组仅为12mmHg;两组治疗后舒张压无显著差异(P>0.05);两组1年内心血管病因住院率比较有显著差异(P<0.05),脑血管病因住院率无显著差异(P>0.05),总心、脑血管事件发生率有显著差异(P<0.05)。结论在单纯收缩期高血压的治疗中,普伐他汀类有效、安全,值得临床推广应用。
Objective To study the efficacy of provastatin on isolated systolic hypertension. Methods Seventy-two patients were randomly divided into control group （n=35） and treatment group （n=37）, both of the two groups were treated with routine antihypertension medication and the treatment group was added provastatin 20mg, once per night, the change for blood pressure and pulse pressure after treatment and cardio cerebral vascular events were analyzed within one year follow-up period. Results After treatment the systolic pressure and pulse pressure had significant difference between the two groups （ P〈0.01 ）, the pulse pressure was averagly lowered 18mmHg in treatment group,12mmHg in control group. There was no significant difference for the diastolic pressure after treatment （P〉0.05）,the admission rate of cardiovascular causes had significant difference in one year between two groups （P〈0.05）, there was no significant difference for the admission rate of cerebral causes （P〉0.05）, there was significant difference for total cardiocerebral vascular events（P〈0.05 ）. Conclusion Provastatin is effective and safe for isolated systolic hypertension treatment, it is worthy of expanding usage in clinical prescription.
出处
《中国现代医药杂志》
2007年第7期17-18,共2页
Modern Medicine Journal of China
关键词
普伐他汀
单纯收缩期高血压
脉压
Provastatin Isolated systolic Hypertension Pulse pressure
