摘要
目的探讨血管内皮生长因子(VEGF)在肺癌患者血清中的表达及其临床意义。方法采用酶联免疫吸附法(ELISA)检测114例确诊的肺癌患者及87例对照者血清VEGF浓度,分别计算VEGF的灵敏度、特异度,分析其与临床特征的关系。结果肺癌患者血清VEGF平均浓度为203.70 ng/L,明显高于对照组的75.21 ng/L;以200.60 ng/L为医学参考值上限,其灵敏度为59.65%,特异度为95.40%;有瘤负荷组患者灵敏度可达到74.68%,而无负荷者仅为25.71%,其差别均有统计学意义(P<0.001)。结论血清VEGF在肺癌中表达较高,可能在肿瘤的增殖、转移中发挥重要作用,是一个有价值的肺癌标记物。
Objective To investigate the expression of serum vascular endothelial growth factor （S-VEGF） in lung cancer patients and its clinical significance. Methods Using enzyme-linked immunosorbent assay （ ELISA）, the levels of S-VEGF were determined in serum from 87 healthy subjects and 114 lung cancer patients who were diagnosed by pathology and/or cytology. Results The mean serum VEGF levels in lung cancer cases were 203.70 ng/L, which was significantly higher than that of healthy subjects （75.21 ng/ L）. While the normal upper value of S-VEGF was 200.6 ng/L according to statistical analysis, the sensitivity and specificity of S-VEGF in lung cancer patients were 59.6% and 95.4% respectively. The sensitivity of S-VEGF in patients with tumor burden was significantly higher than that without tumor burden （74. 68 % vs 25, 71%, P 〈 0. 001 ）. Conclusions S-VEGF has a high expression in lung cancer, which may play a very important role in the growth and metastasis of lung cancer. It is a useful tumor marker of lung cancer.
出处
《临床肺科杂志》
2007年第8期804-804,806,共2页
Journal of Clinical Pulmonary Medicine
关键词
肺癌
血管内皮生长因子
肿瘤标记物
lung cancer
vascular endothelial growth factors
tumor marker
