摘要
为了探索多孔羟基磷灰石陶瓷（ＨＡＣ）作为人工材料修复颅骨缺损的可能性，选健康家兔２４只，切除颅顶骨造成缺损，分别用多孔ＨＡＣ植片及无孔甲基丙烯酸甲脂－苯乙烯共聚物（ＭＭＡＳ）植片修复家兔颅骨缺损，于术后第１，２及３个月处死动物，进行术后反应及组织学观察。结果发现：术后动物精神状态及活动均正常，无头皮下积液。组织学显示在不同阶段，多孔ＨＡＣ植片标本有肉芽组织、纤维组织和新生血管向微孔中生长及成骨细胞形成的骨小梁。界面结构未见异型细胞及炎性细胞浸润。无孔ＭＭＡＳ植片表面有纤维膜形成。实验表明，由于ＨＡＣ具有优良的生物学性能，有可能作为颅骨缺损的修复材料。
In order to investigate the possibility of porous hydroxyapatite ceramics (HAC) in the repair of skull bone defect, twenty four rabbits were used. The bone defect model was created by operation to obtain a defect in parietal bone in a size of 1 cm×1 cm. Filled the defect with HAC and methyl methacrylate syrene copolymer (MMAS) to fill the defect as control. At 1st, 2nd and 3rd months after operation, behavior of the rabbits was observed and then these animals were sacrificed and specimens were examined under microscope. Results showed as follows: after operation, behavior of all animals were normal. By histological examination, it was found that in HAC group, there were granulation tissue, fibrous tissue and newly formed vessels grew into the pores and the osteoblasts formed osseous trabeculae. There was no inflammatory cell infiltration. In the MMAS grafted asea, there was formation of fibrous membrane. It suggested that HAC might be a good material for bone substitute in repair of skull bone defect.
出处
《中国修复重建外科杂志》
CAS
CSCD
1997年第3期129-131,共3页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家自然科学基金
关键词
多孔羟基磷灰石
陶瓷
颅骨缺损
Porous hydroxyapatite ceramics Skull bone defect Repair Experimental study
