摘要
目的旨在观察中药益气养阴活血化痰法对2型糖尿病(T2DM)胰岛素抵抗(Insulin Resistance IR)者白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的影响。方法将入选病人随机分为治疗组和对照组各20例,治疗组采用中药益气养阴活血化痰方口服,并与罗格列酮片相对照,治疗前后观察血糖(BG),糖化血红蛋白(HbA1C),血浆胰岛素(FINS),IL-6,TNF-α水平变化情况。以FINS和胰岛素敏感指数(ISI)评估IR。结果治疗组与对照组治疗前各观察指标无统计学意义(P>0.05),治疗前与治疗后比较有显著差异(P<0.01),两组治疗后比较无统计学意义(P>0.05)。结论益气养阴活血化痰法可能通过抗炎而起到改善胰岛素抵抗的作用。
Objective The aim was to observe the effect to IL-6,TNF-α of invigorating ＂Qi＂ , nourishing ＂Yin＂, promoting blood circulation and dispersing phlegm method of TCM to insulin resistance（IR） in T2DM patients. Methods The selected patients were randomly divided into treatment group and control group ,each group has 20 patients. The treatment group patients took invigorating ＂Qi＂ , nourishing ＂Yin＂, promoting blood circulation and dispersing phlegm formula, the control group patients took Rosiglitazone tablets. The BG , HbA1 C, insulin, FINS, IL - 6 and TNF - α between before treatment and after treatment were observed. IR was evaluated by FINS and ISI. Results There was no statistic significance for each observed targets before treatment between the treatment group and the control groups （P 〉0.05）. There was obvious significance after treatment compared with before treatment（P〈 0.01 ）, and there was no statistic significance after treatment between the two groups （P 〉 0.05 ）. Conclusion Invigorating ＂Qi＂ , nourishing ＂Yin＂, promoting blood circulation and dispersing phlegm method maybe improve IR by anti -inflammation.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2007年第6期1402-1403,共2页
Lishizhen Medicine and Materia Medica Research
关键词
益气养阴活
血化痰法
2型糖尿病
胰岛素抵抗
炎性因子
Promoting blood circulatony and dispersing phlegm method
T2DM
IR
Inflammation factor
