摘要
目的观察截敏祛风汤对大鼠变应性鼻炎的治疗作用。方法选择健康大鼠40只,随机分为截敏祛风汤组(A组)、西替利嗪组(B组)、模型对照组(C组)和正常对照组(D组),每组10只,以卵清蛋白建立大鼠变应性鼻炎模型,用药治疗7天。观察行为学、鼻黏膜光镜和电镜下组织形态学变化。结果C组出现典型的行为学变化,黏膜水肿、嗜酸性粒细胞浸润以及细胞超微结构改变。A、B组上述变化明显减轻,接近D组水平。结论截敏祛风汤可明显改善大鼠变应性鼻炎的症状,减少嗜酸性粒细胞的聚集及活化,减轻变应性炎症反应。
OBJECTIVE To observe the curative effect of Jieminqufeng decoction to the rats with allergic rhinitis. METHODS Fourty Wistar rats were randomly divided into 4 groups. There were Jieminqufeng decoction group （A）, cetirizine group （B）, model control group（C） and normal control group （D）. The rats with allergic rhinitis were established with ovalbumin. The behavioral changes of the rats were observed. The histological and cellular morphological changes were studied with light microscope and transmission electron microscope. RESULTS The model control （C） group had typical symptoms of allergic rhinitis. By light microscope and transmission electron microscope, a lot of eosinophilic granulocytes were found in nasal mucosa. The mucosal cells were lost or destroyed. However, the histological and cellular morphological changes of nasal mucosa in Group A, B were similar to that in Group D. CONCLUSION The Jieminqufeng decoction is an effective drug to treatment of allergic rhinitis. It can decrease the aggregation and activation of eosinophilic granulocytes, lessen inflammatory reaction and block up the allergy.
出处
《中国耳鼻咽喉头颈外科》
北大核心
2007年第3期173-175,共3页
Chinese Archives of Otolaryngology-Head and Neck Surgery
关键词
鼻炎
变应性
常年性
截敏祛风汤
组织学
Rhinitis, Allergic, Perennial
jieminqufeng decoction
Histology
