伴心房颤动的老年慢性心力衰竭患者炎症因子和血管紧张素Ⅱ水平的变化被引量：7

Changes of levels of inflammatory factors and ATⅡ in the elderly with chronic heart failure and atrial fibrillation

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摘要目的:分析慢性心力衰竭患者炎症因子[白细胞介素-6(IL-6)、C反应蛋白(CRP)]和血管紧张素Ⅱ(ATⅡ)水平变化,并探讨其在慢性心力衰竭患者心房颤动中的作用。方法:选择稳定的老年慢性心力衰竭患者67例(其中伴有心房颤动患者32例和窦性节律患者35例),并选择28例匹配的正常人作为对照组,检测其IL-6、CRP和ATⅡ水平,并通过超声心动图测定慢性心力衰竭患者的左室射血分数(LVEF)。结果:慢性心力衰竭患者的IL-6、CRP和ATⅡ水平较正常人明显增高(P<0.01),并且IL-6、CRP随LVEF的降低而逐渐升高,呈显著负相关。伴有心房颤动患者较窦性心律患者IL-6、CRP和ATⅡ水平明显增高,差异也有显著性。结论:炎症和肾素-血管紧张素-醛固酮系统可能在慢性心力衰竭患者的心房颤动中具有重要作用。 Objective To study the changes in levels of inflammation factors including interleukin-6 （IL-6） and C-reactive protein （CRP）, and levels of angiotensin Ⅱ （AT Ⅱ ） in the elderly with chronic heart failure, and explore the effects of those analytos on atrial frbrillation in the patients. Methods The levels of IL-6, CRP, and AT Ⅱ were measured in 67 elder patients with stable chronic heart failure and 28 healthy control subjects, respectively. Left ventricular ejection fraction （LVEF） was detected by echocardiography in all patients. Results The levels of IL-6, CRP, and AT Ⅱ in the subjects with chronic heart failure were much higher than those in the control subjects （P 〈 0.01 ）. The IL-6 and CRP levels were negatively correlated with LVEF and they differed significantly between the patients with atrial fibrillation and those who were in sinus rhythm. Conclusion Both inflammation and renin-angiotensin-aldosterone system may play an important role in atrial fibrillation in patients with chronic heart failure.

作者宋浩明罗明沈艺梁四维

机构地区同济大学附属同济医院心血管内科

出处《实用医学杂志》 CAS 2007年第11期1630-1632,共3页 The Journal of Practical Medicine

关键词心力衰竭充血性心房颤动白细胞介素6 C反应蛋白血管紧张素Ⅱ Heart failure,congestive Atrial fibrillation Interleukin-6 C-reactive protein Angiotensin Ⅱ

分类号 R541.6 [医药卫生—心血管疾病]

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