摘要
目的探讨前列腺硬化性腺病与小腺泡结构前列腺癌的病理鉴别诊断。方法报道1例前列腺硬化性腺病,结合有关文献从临床、病理形态和免疫组化等方面分析它与前列腺癌的区别。结果硬化性腺病在HE切片中与小腺泡结构前列腺癌十分相似,但缺乏明显增大的核仁,腺管周围有增厚的基膜以及34βE12、p63、CK5/6、S-100蛋白和SMA标记(+)的基底细胞围绕。结论前列腺硬化性腺病是一种罕见的容易误诊为前列腺癌的良性病变,有明显的结构和细胞学不典型性以及AM-ACR标记(+)等异常表现。富于细胞性间质,腺管周围有完整的基底细胞层围绕和基底细胞的肌上皮细胞化生,是与癌鉴别的重要特征。
Purpose To investigate the pathologic differential diagnosis between sclerosing adenosis and adenocarcinoma of the prostate. Methods We reported a case of sclerosing adenosis of the prostate, which histologically mimicked adenocarcinoma of the prostate. Based on related literatures, we analyzed the differences between them in the aspects of clinical, histopathologic and immunohistochemical Endings. Results Sclerosing adenosis and adenocarcinoma of prostate were similar in morphology, However, prominently enlarged nuleoli were not present in sclerosing adenosis of the prostate, which was composed of glands surrounded with thickened basal membrane. Immunohistochemistry showed that the glands were lined by basal cells positive for keratin 34βE12, p63, cytokeratin 5/6, S-100 protein and smooth muscle actin （SMA）. Conclusions Sclerosing adenosis of the prostate, an uncommon pseudomalignant benign lesion, has structural and cytologic atypia and AMACR positivity, and therefore it is easily misdiagnosed as adenocarcinoma of prostate. The cellular stroma and the glands surrounded by integral basal ceils and myoepithelial metaplasia of the basal ceils are important distinctive features that should enable the lesion to be distinguished from prostatic adenocarcinoma.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2007年第2期201-203,共3页
Chinese Journal of Clinical and Experimental Pathology
关键词
前列腺疾病
硬化性腺病
鉴别诊断
免疫组织化学
prostatic diseases
sclerosing adenosis
diagnosis, differentiation
immunohistochemistry
