摘要
目的：探讨双黄连注射剂引起过敏性休克的流行病学特点与诱发因素。方法：通过检索1978～2005年医药学期刊,收集双黄连注射剂致过敏性休克病案72例,应用文献计量学方法对病案的流行病学资料进行分析。结果：资料中,18～44岁的青年患者比例最高（46.48%）;男性37例（52.11%）,女性34例（47.89%）;患者原发疾病中上呼吸道感染比例最高（68.75%）;过敏性休克多发生在给药30 m in内（89.36%）;7例患者抢救无效死亡,死亡率9.72%。结论：双黄连注射剂可引起较严重的甚至危及生命的过敏性休克,其发生机制涉及患者体质等多方面因素。
AIM： To investigate the epidemiological characteristic and causative factors of anaphylactic shock caused by Shuanghuanglian Injection （Flos Lonicerae Japonicae, Radix Scuteilariae, Fructus forsythiae）. METHODS ： Domestic medicine periodicals were searched between 1978 and 2005, and 72 cases with anaphylactic shock caused by Shuanghuanglian Injection were analysed by literature metrologic method. RESULTS： There were large proportion of young sufferers from age 18 to 44 in the case reports, and male 52.11%, female 47.89% , the primary affections were mainly upper respiratory tract infection, the occurrence of ADRs was commonly within 30 mins after injection, seven patients died of the terrible anaphylactic shock. CONCLUSION： Shuanghuanglian Injection may induce dangerous, even fatal anaphylactic shock, its mechanism includes many factors, such as patient＇s physical constitution.
出处
《中成药》
CAS
CSCD
北大核心
2007年第5期638-641,共4页
Chinese Traditional Patent Medicine
基金
国家食品药品监督管理局药品评价中心项目(2005B0601)
关键词
双黄连注射剂
过敏性休克
不良反应
Shuanghuanglian Injection
anaphylactic shock
adverse reaction
