摘要
目的探讨富露施治疗COPD急性加重期患者的临床疗效及其对患者体内氧化/抗氧化失衡状态的影响。方法96例COPD急性加重期住院患者被随机分为A、B两组,两组均采用抗菌活性相似的抗生素及茶碱制剂进行治疗,A组患者在此治疗基础上给予富露施600mg泡腾2次/d,疗程为14d,C组为正常对照组。对A、B两组患者分别于治疗前后观察主要症状、体征进行病情评分,测定FEV1,抽取外周血测定LPO及SOD的水平。结果与正常对照组相比,COPD急性加重期患者体内过氧化脂质(LPO)显著增高,同时超氧化物歧化酶(SOD)显著下降,治疗前A、B两组各项指标均差异无显著性(P>0.05),A、B两组患者经治疗后症状、体征及肺功能、氧化/抗氧化失衡均较治疗前有明显改善,富露施应用14d后,A组患者的病情综合评估及肺功能改善明显优于B组,A组SOD活力的增强及LPO水平的下降与B组相比差异具有显著性(P<0.05)。结论富露施不仅可以改善COPD急性加重期患者的病情及肺功能,而且通过直接和间接作用改善患者体内氧化/抗氧化的失衡,对COPD的防治起着积极的作用。
[Objective] To assess the clinical effect and anti-oxidative ability of Fulushi on patients with chronic obstructive pulmonary disease （COPD）. [Methods] 96 patients with COPD in acute phase were randomly divided into the A group and the B group. 48 patients in A group were treated with the routine antibiotic and Theophyline, 48 patients in B group were treated with the intervention of Fulushi above the routine medicine. The clinical symptoms, signs, FEV1 and the blood levels of superoxide dismutase （SOD） and lipid peroxides （LPO） were measured before and after treatment. [Results] Before the treatment, in all patients in acute phase of COPD, LPO in serum significantly increased, but SOD in serum and pulmonary function significantly decreased when compared with those in healthy subject （C group）, and there were no significant difference between A group and B group （P 〉0.05）. After treatment for 14 days, the main symptoms, signs and FEV1 were significantly improved, and the disorder state of oxygen free radical metabolism were obviously adjusted in both A group and B group, but in A group all the indexes were better than those in B group （P 〈0.05）. No obvious adverse effects were found in the period of treatment. [Conclusions] Fulushi can attenuate the oxidant/antioxidant imbalance in COPD patients through its direct and indirect antioxidation against free radical induced by airway inflammation, and its clinical application can improve the symptom and pulmonary function of patients, so it may play a important role in the prevention and treatment of COPD.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第9期1123-1125,共3页
China Journal of Modern Medicine
