摘要
目的:探讨类风湿性关节炎(RA)患者血清白细胞介素1α(IL-1α)白细胞介素1β(IL-1β)、白细胞介素17(IL-17)以及护骨因子(OPG)水平检测的临床意义。方法:采用酶联免疫吸附试验检测50例RA患者及32例正常对照组血清中IL-1α、IL-1β、IL-17、OPG和CRP的水平。结果:RA患者IL-1α、IL-1β、IL-17、OPG、和CRP的水平明显高于正常对照组(P<0.01)。结论:IL-1α、IL-1β、IL-17、OPG、CRP在判断RA的活动性以及骨质破坏等方面有较高的敏感性。
Objective： To study the diagnotic value of the IL-1α, IL-1β, IL-17 and OPG levels in Rheumatoid arthritis （RA）patients. Methods：The levels of IL-1α,IL-1β,IL-17,OPG in 50 RA patients and 32 nomal controls（NC） were detected by using enzyme linked immunosorbent assays （ELISA）. Results： The levels of IL-1α, IL-1β, IL-17and OPG in RA patients were significantly higher than those in NC simultaneously（P〈0.01）, the levels of IL-1α, IL-1β, IL-17and OPG wer differemt between active RA and stable RA. Conclusion： IL-1α, IL-1β, IL-17 and OPG are more sensitive index for detecting the activity and bone erosion of rheumatoid arthritis and may play an importaint role in monitoring the therapeutic effects and prognosis of RA.
出处
《四川生理科学杂志》
2007年第1期37-39,共3页
Sichuan Journal of Physiological Sciences
