摘要
目的评价Tokuhashi修正评分在脊柱转移瘤患者生存时间预测中的价值。方法选择我院收治的有随访资料的脊柱转移瘤患者447例,采用Tokuhashi修正评分系统进行综合评分,根据不同分值分成3组,0～8分为A组,9～11分者为B组,12～15分为C组。对3组及不同原发肿瘤部位和恶性程度患者的生存时间数据进行生存分析,对Tokuhashi修正评分与生存时间的关系进行相关性分析。结果患者Tokuhashi修正评分平均为8.23分,平均生存时间10.2月,中位生存时间7.9月,1年生存率为38%。肿瘤原发于肺、肝、胃肠道、食道、膀胱和胰腺者155例,中位生存时间4.7月(平均5.8月);原发于甲状腺、乳腺、前列腺者146例,中位生存时间12月(平均13.3月);原发于肾脏、淋巴、卵巢和子宫,以及原发灶不明者146例,中位生存时间7.1月(平均9.4月)。A组211例,中位生存时间4月(平均5月);B组147例,中位生存时间10月(平均12月);C组89例,中位生存时间29月(平均29月)。不同原发肿瘤部位及恶性程度患者和不同Tokuhashi修正评分患者生存时间的差异均有统计学意义(P<0.01或0.0001)。Tokuhashi修正评分与生存时间呈正相关(r=0.833,P<0.001)。结论Tokuhashi修正评分与脊柱转移瘤患者的生存时间呈正相关,可作为脊柱转移瘤治疗决策的重要参考指标。对于单发的、原发瘤恶性程度相对较低的脊柱转移瘤,Tokuhashi修正评分12～15分者,采取积极的手术治疗可望取得较好的疗效。
Objective To evaluate the predictive value of the Tokuhashi revised scoring system for the life expectancy of patients with spinal metastases. Methods A retrospective review of 447 patients with spinal metastases was performed, which comprised 291 men and 156 women with a mean age of 56. 1 years. All of the patients were scored with the Tokuhashi revised scoring system based on the available clinical, pathological and radiographic data. The relation between the survival time and the Tokuhashi revised score was analyzed. Results The patients had a median survival time of 7.9 months and a mean Tokuhashi revised score of 8.23 points. The median survival time of 155 patients with high grade primary tumor of lung, liver, gastrointestinal tract, esophagus, bladder and pancreas was 4. 7 months. The median survival time of 146 patients with low grade primary tumor of thyroid, breast and prostate was 12 months. The median survival time of 146 patients with medium grade primary tumor of kidney, lymphoma, ovary and uterus, and unknown primary tumor was 7. 1 months. The median survival time of 211 patients with the Tokuhashi revised score of 0 to 8 points was 4 months. The median survival time of 147 patients with the Tokuhashi revised score of 9 to 11 points was 10 months. The median survival time of 89 patients with the Tokuhashi revised score of 12 to 15 points was 29 months. The differences between the groups were significant （P〈0. 01 or 0. 0001）. The Tokuhashi revised score was positively correlated with survival time （r=0. 833, P〈0. 001）. Conclusion The Tokuhashi revised score could support decision making with reliable estimation of life expectancy of patients with spinal metastases. Surgery could be a better choice to extend life span for those patients with solitary spinal metastasis of slow-growth primary tumor and those with the Tokuhashi revised score of 12 to 15 points.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2007年第3期488-491,共4页
Journal of Sichuan University(Medical Sciences)
基金
国家自然科学基金(批准号30200286)资助
