摘要
目的:探讨枸橼酸氢钾钠降低草酸钙结石成石危险性的机制。方法:经B超、X线、尿生化检查诊断为肾或输尿管含钙结石18例,其中肾结石16例,输尿管结石2例。测定口服枸橼酸氢钾钠前后尿生化参数进行比较。结果:口服枸橼酸氢钾钠2周时,尿pH值、枸橼酸、(可溶解钙×枸橼酸)/(总钙×草酸)明显升高,尿钙降低,与服用前比较,差异均有统计学意义(P<0.05)。24h尿中尿酸、草酸变化无统计学意义。结论:枸橼酸氢钾钠可有效降低含钙结石成石危险性。
Objective：To investigate the mechanism of potassium sodium hydrogen citrate inhibiting the formation of calcium stone. Methods：A total of 18 cases of 9 men and 9 women calcium stone formers were studied, 16 with renal stones and 2 with ureteral stones. All cases were identified by ultrasound, plain film of kidney-ureter bladder and urine biochemical examination. Collected 24 hour urine on their habitual, and after 2 weeks on potassium sodium hydrogen citrate. Results： Urine pH, 24-hour citrate excretion, the value （iCa^2＋×Cit）/（ TCa^2-Ox） increased; 24-hour calcium excretion with the difference being significant （ P 〈0.05） after 2 weeks treatment. But the change of 24-hour uric acid excretion, 24-hour oxalic acid excretion are insignificant （ P 〉0.05）. Conclusions：Taking potassium sodium hydrogen citrate could inhibit the formation of calcium stone effectively.
出处
《临床泌尿外科杂志》
2007年第4期287-288,291,共3页
Journal of Clinical Urology
关键词
尿结石
枸橼酸氢钾钠
成石危险性
Stone
Potassium sodium hydrogen citrate
Risk factors
