摘要
目的观察盐酸戊乙奎醚(长托宁)对感染性休克患者胃黏膜酸度的影响。方法选择感染性休克患者40例,随机分为两组,测定其胃黏膜CO2张力(PCO2),计算pHi,同时测定动脉血乳酸值。实验组在测定第1次pHi后即给予长托宁4mg持续1h静脉泵入,每12h1次。结果所有患者在进入ICU时pHi均值均偏低(7.28￣7.29),72h后,两组患者的pHi均较入ICU时有所升高(P<0.05),但实验组较对照组升高更明显(P<0.05)。血乳酸值在入ICU时都高于正常值,随着住院时间的延长,均呈下降趋势,但实验组较对照组下降更明显(P<0.05)。结论感染性休克患者应用长托宁72h后,Phi明显升高,胃肠道的微循环灌注有明显改善。
[Objective] To evaluate the effects of penehyclidime hydrochloride on gastric mucosal pH （pHi） with gastric tonometry in patients with septic shock. [Methods] Forty patients with septic shock admitted to ICU were divided into 2 groups randomly. When the patient entered, a nasogastric tonometry catheter was used to measure gastric mucosal pHi, also a simultaneous arterial blood sample was obtained for measurement of blood gas analysis and blood lactate. In penehyclidime hydrochloride treated group, after pHi and blood lactate were measured for the first time, penehyclidime hydrochloride was given in a dose of 4mg intravenously once per 12 hours. [Results] In all patients, pHi value decreased to certain extent, being about 7.28-7.29. At 72 hours, pHi value significantly increased as comparison to the first measured value （P 〈0.05）, and also much higher in penehyclidime hydrochloride treated group than that in the controls at the same time （P 〈0.05）. The value of lactate increased when admitted in 2 groups. At 72 hours, lactate levels markedly decreased comparing with the first measured value （P 〈0.05） in 2 groups, but it was much lower in penehyclidime hydrochloride treated group than control group at the same time （P 〈0.05）. [Conclusions] Intravenous injection of penehyclidime hydrochloride can significantly elevate pHi value and decrease blood lactate levels. It suggested that penehyclidime hydrochloride treatment can improve gastrointestinal blood perfusion.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第7期856-858,861,共4页
China Journal of Modern Medicine
关键词
盐酸戊乙奎醚
感染
休克
胃黏膜酸度
乳酸
penehyclidime hydrochloride
septic
shock
gastric mucosal pH
lactate
