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头孢曲松T>MIC达标的影响因素分析 被引量：2

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摘要 目的:分析不同剂量和不同静脉滴入速度对头孢曲松T>MIC的影响,为临床合理应用该药提供理论依据。方法:以一室药代动力学模型为基础,设定头孢曲松的最低抑菌浓度(MIC)为8%g·ml-1,T>MIC达标值为45%,计算头孢曲松在采用不同的剂量和给药速度时的T>MIC,分析剂量和给药速度对T>MIC达标的影响。结果:临床常用的四种剂量都可使头孢曲松的T>MIC达标,增加给药剂量可使头孢曲松的T>MIC明显增加,而延长滴注时间对提高T>MIC的作用不明显。结论:头孢曲松可选择每日剂量一次给药,对中介细菌应将每日剂量增加至1g以上,分1￣2次静脉给药。
作者 姚国新 汤远亮 张丽华
机构地区 中山大学附属东华医院
出处 《现代医药卫生》 2007年第10期1452-1453,共2页 Journal of Modern Medicine & Health
关键词 头孢曲松 T〉MIC 达标 剂量 给药速度
分类号 R9 [医药卫生—药学]
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  • 1Thoma GV. Beta-lactam antibiotics: is continuous infusion the preferred method of administration? [J]. Ann Pharmacother,1995,29(4) :415 - 423.
  • 2Zhao X, Drlica K. Restricting the selection of antibiotic-resistant mutants:a general strategy derived from fluoroquinolone studies [J]. Clin Infect Dis ,2001,33(Suppl 3) :S147 - S156.
  • 3Zhao X, Drlica J. Restricting the selection of antibiotic-resistant mutant bacteria:measurement and potential use of the mutant selection window[J]. J Infect Dis,2002,185 (4): 561 - 567.
  • 4Mattoes HM. Comparative pharmacokinetic and pharmacodynamic profile of piperacillin / tazobactam 3. 375g q4h and 4.5g q6g [J]. Chemotherapy, 2002,48(2): 59 - 63.
  • 5Buijk SL. Pharmacokinetics of ceftazidime in serum and peritone al exudate during continuous versus intermittent administration to patients with severe intra-abdominal infections[J]. J Antimicrob Chemother,2002,49(1): 121 - 129.
  • 6Fujii R, Yoshioka H, Fujitam K, et al. Pharmacokinetic and clinical studies of cefdinir in the pediatric field. Pediatric Study Group of Cefdir[J]. J Antibiotics, 1991,44(10) :1168- 1191.
  • 7Ursula F. Integration of pharmacokinetics and pharrmacodynamics of imipenem in a human adapted mouse model [J]. Antimicrob Agents Chemother, 1991,35(9): 1905 - 1910.
  • 8Craig WA. Interrelationship between pharmacokinetics and pharmacodynamics in determining dosage regimens for broad-spectrum cephalosporins [J]. Diagn Microbiol Infect Dis, 1995,22(1 -2):89-96.
  • 9Lutsar I, Ahmed A. Pharmacodynamics and bactericidal activity of ceftriaxone therapy in experimental cephalosporin-resistant pneumococcal meningits [J]. Antimicrob Agents Chemother,1997,41(11) :2414 - 2417.
  • 10Craig WA. Antimicrobial resistance issues of the future[J]. Diagn Microbiol Infect Dis, 1996,25(4):213- 218.

共引文献33

同被引文献20

  • 1王宏.抗菌药物PK/PD参数与临床给药方案分析[J].中国药师,2006,9(9):854-856. 被引量：12
  • 2汤远亮,姚国新,张丽华.不同剂量和给药速度对头孢唑啉T>MIC达标的影响[J].海峡药学,2007,19(6):23-24. 被引量：2
  • 3卫生部合理用药专家委员会.中国医师药师临床用药指南[M].重庆:重庆出版集团重庆出版社,2009:700-701.
  • 4Dagan R, Kugman KP, Craig WA, et al. Evidence to support the rati- onale that bacterial eradication in respiratory tract infection ,is an im- portant aim of antimicrobial therapy [ J ]. J Antimocrob Chemother, 2001,47:129-140.
  • 5Cazzola M, Di Pema F, Boveri B, et al. Interrelationship between the pharmacokinetics and pharmacodynamics of cefaclor advanced formu- lation in patients with acute exacetbation of chronic bronchitis [ J]. J Chemother ,2000 ,12 : 216-222.
  • 6Shea KM, Cheatham SC, Smith DW, et al. Comparative pharmacody- namics of intermittent and prolonged infusions of piperacillin/tazobac- tam using Monte Carlo simulations and steady-state pharmacokinetic data from hospitalized patients [ J ]. Ann Pharmacother, 2009, 43 ( 11 ) :1747 -1754.
  • 7Peric M, Browne FA ,Jacobs MR, et al. Activity of nine oral agents a- gainst gram-positive and gram-negative bacteria encountered in com- munity-acquired infections : use of pharmacokinetic/pharmacodynamic breakpoints in the comparative assessment of beta-lactam and macroli- de antimicrobial agents[ J]. Glin Ther,2003,25 (1) :169-177.
  • 8Craig W. Phannacodynamics of antimicrobial agents as a basis for de- termining dosage regimens [ J]. Eur J Clin Microbiol Infect Dis, 1993, 12(Suppl 1 ) :S6.
  • 9Dagan R,Klugman KP,Craig WA,et al.Evidence to support the rationale that bacterial eradication in respiratory tract infection is an important aim of antimicrobial therapy[J].J Antimocrob Chemother,2001,47(2):129.
  • 10Cazzola M,Di Perna F,Boveri B,et al.Interrelationship between the pharmacokinetics and pharmacodynamics of cefaclor advanced formulation in patients with acute exacetbation of chronic bronchitis[J].J Chemother,2000,12(3):216.

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现代医药卫生
2007年 第10期

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