摘要
目的观察宫颈鳞癌患者T细胞亚群的漂移状态。方法采用ELISA法,对65例宫颈鳞癌患者和40例正常人群的血清中的IL-2、IFN-γ、IL-4、IL-10进行测定。结果宫颈鳞癌患者血清中IL-2、IFN-γ水平较正常对照组明显降低(P<0.01),宫颈鳞癌患者血清中IL-4、IL-10高于对照组,统计处理有显著性差异(P<0.05)。结论宫颈鳞癌患者存在典型的Th2漂移现象,机体免疫抑制,导致肿瘤发生,同时为宫颈鳞癌的生物治疗提供靶点。
Objective To detect the percentage of Th1/Th2 subsets in the peripheral blood of patients with cervical squamous cell carcinoma. Methods Levels of IL - 2, IFN - γ, IL - 4 and IL -10 were determined using ELISA in plasma from 65 patients with cervical squamous cell carcinoma and 40 healthy women. Results The plasmatic levels of IL -2 and IFN - γ in patients were signifi- cantly lower than those in the controls（ P 〈0. 01 ） ,by contrast,the plasmatic levels of IL -4 and IL - 10 were lower（ P 〈 0. 01 ）. Conclusion There are disregulation of Th1/Th2 type cytokines in peripheral blood of patients with cervical squamous cell carcinoma,the imbalance of Th1/Th2 shifting to Th2 is correlated with the genesis and development of cervical squamous cell carcinoma, which is helpful for further biotherapy.
出处
《医药论坛杂志》
2007年第5期24-25,共2页
Journal of Medical Forum
基金
河南省医学科技创新人才工程项目(编号200303056)
