摘要
目的:建立腹部开放伤合并海水浸泡致急性肾功能衰竭动物模型,为海战伤的研究提供技术平台。方法:成年杂种犬20只,致腹部开放伤后随机分为海水浸泡组和对照组,每组10只。观察各时间点生存率、体温、血压、肾功、血气、渗透压、病理等变化。结果:经过海水浸泡后,动物立即出现低血压、低温、高渗,然后逐渐出现代谢性酸中毒,血肌酐和血尿素氮逐渐升高,病理也出现急性肾衰竭表现,与对照组比较有显著性差别(P<0.05)。结论:该模型具备战伤合并海水浸泡的伤情变化特点,出现了典型的急性肾衰的病情特点,可行且重复性好,适用于海战伤致急性肾衰的病理生理和相应治疗手段的研究。
Objective： To establish a canine model of acute renal failure （ARF） caused by open trauma and seawater immersion that could be used for investigation. Methods ：Trauma model was established with twenty grown-up healthy dogs. All dogs were subjected to open abdominal injury,and randomly separated into control group（ n = 10） and immersion group（ n = 10）. Observe the numerical values of survival rate, anus temperature, MAP, Scr, BUN, Osm, HCO3^- , electrolyte and pathologic. Results：After immersion,the dogs presented obvious hypotensive, hypothermia, hyperosmolality, and presented acid-base imbalance eventually. BUN and Scr raised up as time went by and the pathologic showed typical ARF＇s change. Conclusions：The model is featured with the typical physiopathologic changes after wound and immersion, and the model is practicable, reasonable and repeatable for investigating the feature of ARF caused by open trauma and seawater immersion.
出处
《军医进修学院学报》
CAS
北大核心
2007年第2期135-137,共3页
Academic Journal of Pla Postgraduate Medical School
