摘要
目的分析三维适形放疗食管癌患者的临床物理参数，为进一步优化食管癌适形放疗计划，减少放射性肺炎的发生提供参考标准。方法回顾性总结55例食管癌患者的三维适形治疗计划及临床资料，并对相关因素进行单因素、多因素的统计分析。结果55例中发生放射性肺炎12例，其中2级9例，3级3例。与放射性肺炎相关的因素有二程放疗、总剂量、后半程射野数、总射野数、肺V10、肺V15、肺V20、肺V25、肺D平均、食管GTVV50。Logistic多元回归分析显示二程放疗、后半程射野数、肺V25为放射性肺炎发生的独立影响因素。结论食管癌二程放疗、后半程射野数、肺V25系影响放射性肺炎发生的主要因素。
Objective To evaluate the clinical factors and physical parameters related to radiation-induced pneumonitis in oesophageal carcinoma treated with three-dimensional conformal radiotherapy （3DCRT）. Methods From October 2000 to December 2003, 55 esophageal carcinoma patients were retrospectively reviewed with clinical factors and physical parameters in relation to radiation-induced pneumonitis. Logistic regression model was used to test their relativities. Results According to the RTOG criteria, pneumonitis was observed in 12 patients, the rate of incidence 22%, with 9 in grade Ⅱ, 3 in grade Ⅲ Secondary-course radiotherapy, total dose, the late-course irradiation beams, total irradiation beams, lungs V10, lungs V15, lungs V20, lungs V25 and lungs Dmean, and oesophageal GTVV50 were significantly correlated with radiation-indueed pneumonitis. Multilogistic regression analysis showed that secondary-course radiotherapy, the late-course irradiation beams and lungs V25 were the independent inducing factors for pneumonitis, Radiation-induced pneumonitis had no significant effect on the survival of esophageal carcinoma. Conclusions There are no significantly difference in the radiation-induced pneumonitis with the two model of total-course 3D-CRT and the secondary-course 3D-CRT. Secondary-course radiotherapy, the late-course irradiation beams and lungs V25 are significantly associated with the pneumonitis in oesophageal carcinoma patients treated with 3D-CRT.
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2007年第2期161-164,共4页
Chinese Journal of Radiological Medicine and Protection
基金
教育部高等学校青年教师教学科研奖励计划基金资助项目（2001125）
河北省自然科学基金资助项目（C2005800802）
关键词
食管癌
放射疗法
三维适形放疗
放射性肺炎
Esophageal carcinoma
Radiotherapy
Three-dimensional conformal radiotherapy
Radiation-induced pneumonitis
