摘要
目的研究中药牛膝的化学成分。方法采用大孔树脂、硅胶柱色谱、制备型HPLC色谱等方法分离中药牛膝中的化学成分,依据这些化合物的理化性质和1H-NMR1、3C-NMR等波谱数据进行结构鉴定。结果从牛膝中分离鉴定了5个化合物,分别为:旌节花甾酮A(stachysterone A,1)、podecdysone C(2)、β-蜕皮甾酮(β-ecdysterone,3)、25-R-膝甾酮(25-R-inokosterone,4)、25-S-牛膝甾酮(25-S-inokosterone,5)。结论化合物1、2为首次从牛膝中分离得到。
Objective To isolate the constituents from Achyranthes bidentata B1. and elucidate their structures. Methods The constituents were isolated by macroporous resin, silica gel column chromatography and HPLC. The UV, ^1H-NMR, ^13C-NMR spectroscopic analyses were employed for the structural identification. Results Five compounds were identified as： stachysterone A（1）, podecdysone C（2）,β-ecdysterone（3）, 25-（R ）-inokosterone （4）, 25-（ S ）-inokosterone （ 5 ）. Conclusions Compounds 1 and 2 were isolated from Achyranthes bidentata B1. for the first time.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2007年第4期207-210,共4页
Journal of Shenyang Pharmaceutical University
基金
辽宁省科学技术基金资助项目(20051026)
关键词
牛膝
甾酮
化学成分
结构鉴定
Achyranthes bidentata B1.
phytosterone
chemcal constituents
structural identification
