摘要
目的:通过分析RasP21蛋白在各组织类型的腺性膀胱炎(Cystitis glandularis:CG)的表达,提高对CG的认识。方法:采用免疫组织化学两步法,测定腺性膀胱炎组织60例、正常膀胱黏膜10例石蜡切片中的RasP21蛋白的表达。结果:RasP21在60例各组织类型腺性膀胱炎即:①移行细胞型;②肠上皮型;③前列腺上皮型;④混合型。各型阳性表达率分别为20%(7/35)、42.86%(6/14)、33.33%(2/6)、40%(2/5),移行细胞型与肠上皮型组比较,肠上皮型阳性表达高(P<0.05);后两者病例少差异无统计学意义。正常膀胱黏膜组织中RasP21无阳性表达。结论:腺性膀胱炎可能是正常膀胱黏膜发展成膀胱癌的一个中间阶段,RasP21免疫组化阳性的移行细胞型腺性膀胱炎,尤其肠上皮型腺性膀胱炎可能更具有癌变潜能,临床治疗注意随访。
Objective： To investigate expression of RasP21 in Cystitis glandularis （CG） and to research whether CG is one of pre-malignant lesion and which subtype has much more malignant potential. Methods： Immunohistochemistric method was used to demonstrate the expression of RasP21 in 60 cases of CG and 10 cases with normal bladder tissue. Result： Normal transitional epithelioid cells indicated negative for RasP21. Among the 60 CG cases,17 cases showed positive, and the rate of expression was 28.33%（17/60） That of the typical subtype and intestinal subtype were 20%（7/35） and 42.86%（6/14） in each,with differential expressions between them（ P 〈0.05）. Conclusion： Cystitis glandularis may be a pre-malignant lesion in bladder, especially the intestinal subtype CG. The CG cases with RasP21-positive should need a regular followed-up for early detection of bladder cancer.
出处
《广西医科大学学报》
CAS
北大核心
2007年第1期33-35,共3页
Journal of Guangxi Medical University
基金
广西自然科学基金资助项目(No0007043)
