摘要
用红藻氨酸（ＫＡ）１０ｍｇ／ｋｇ（ｓ．ｃ）诱发大鼠出现癫病发作一个月后，经免疫细胞化学方法观察大鼠脑内神经胶质原纤维酸性蛋自（ＧＦＡＰ）－免疫反应产物的查化。发现海马的ＣＡ１，ＣＡ２，海马下脚和腹侧海马的海马门都位以及梨状皮层，内嗅皮层，隔区，杏仁核，伏隔核和尾核尾部的ＧＦＡＰ免疫染色阳性明显增强，这一现象可能与动物癫痫发作及发作后，癫痫敏感脑区的神经元损伤有关。
Seizure episodes were induced by administration of kainic acid (10mg/ kg s.c.) in the Sprague-Dawley rats. One month later, the changes of glial fibrillary acidic protein (G F A P)- immunoreactive elements in the rat brain were examined by using immunocytochemical method. Intensive GFAP-im munostainings were found in CA1, CA2, subiculum and ventral hilus of hippocampal formation as well as related areas including amygdaloid, piriform, entorhinal cortex, septum area, accumbens and caudal part of caudate putamen.This phenomenon may associated with neuronal damage during and after seizure episodes.
出处
《神经科学》
SCIE
CAS
1996年第2期73-78,共6页
Chinese Journal of Neuroscience
关键词
癫痫
敏感性
神经胶原原纤维
酸性蛋白
seizure susceptibility
kainic acid
glial fibrillary acidic protein (GFAP)
