摘要
目的:探讨我院2005年儿科院内感染常见致病菌的分布及对抗生素的耐药情况,为临床合理用药提供依据。方法:3001例院内感染患儿,根据感染部位不同,采集血液、痰、分泌物、便及尿液作为检测标本,采用VITEK-2全自动细菌鉴定仪进行细菌鉴定;药物敏感试验使用K-B法;采用WHONET软件对耐药数据进行分析。结果:共检测标本3024份,分离出细菌232株,革兰阴性菌为首要致病菌,占60%,其中肺炎克雷伯菌、大肠埃希菌、液化沙雷菌列前3位。革兰阳性菌占40%,其中凝固酶阴性耐甲氧西林葡萄球菌的检出率为35%。大肠埃希菌产超广谱β-内酰胺酶(ESBLs)为55%,肺炎克雷伯菌产ESBLs为51%。革兰阳性球菌敏感药物为万古霉素(耐药率0)、替考拉宁(耐药率0),对红霉素、克磷霉素、青霉素、苯唑西林的耐药率均大于50%;革兰阴性杆菌较敏感药物为亚胺培南、美罗培南(耐药率0),对头孢二代、三代的耐药率已高达50%。结论:儿科院内感染常见致病菌耐药较严重,合理运用抗生素对控制儿童院内感染及指导临床用药十分重要。
Objective： To study the situation of pathogenic bacteria of pediatric infection in hospital, so can guide clinical doctors use antibiotic rationally. Methods： The urine, secretions, stools, blood and sputum of children patients were collected to be used as the specimen. Identification of bacteria performed by VITEK -2; Antimicrobial susceptibility of the clinical isolates collected were tested by Kirby - Baue rmethod. The results were analyzed according to NCCLS by WHONET 5 software. Results ： Among 232 strains bacteria from 3024 samples, gram negative bacteria was 60%, E -coli , Klebsiella, serratia liquefaciens were ranked respectively. Gram positive bacteria was 40%, in which MRCNS was 35%. ESBLs - positive in E coli was55 % , in klebsiella pneumoniae was 51%.. Drugs of sensitivity for Gram positive coccus were vancomycin （0）, teicoplanin （0） ; Resistant rates of erythromycin, clindamycin, pneicilin were more than 50%, and the drugs of sensitivity for Gram negative were imipenem （0%） , merropenem （0） ; Resistant rates of the second and third cephalosporins were high to 50%. Conclusion： Bacterial resistance is a serious problem. It is instructive that use antibiotic rationally for controlling children infection in hospital.
出处
《中国妇幼保健》
CAS
北大核心
2007年第11期1480-1482,共3页
Maternal and Child Health Care of China
关键词
儿童
感染
致病菌
抗药性
Child
Infection
Pathogenic bacteria
Drug resistance
