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血管细胞黏附分子-1在肺间质纤维化肺血管损害中的作用 被引量：6

Role of VCAM-1 in the vascular injury of pulmonary fibrosis
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摘要 目的:探讨血管细胞黏附分子-1(VCAM-1)在博莱霉素(BLM)致大鼠肺纤维化肺组织中的表达及其在肺血管损害中的作用.方法:采用免疫组化方法结合图像分析处理系统,研究VCAM-1在博莱霉素致肺纤维化大鼠肺组织中的免疫反应.结果:在正常对照组,VCAM-1大鼠肺组织中呈弱表达,分布于肺泡上皮细胞、细支气管上皮细胞、肺泡巨噬细胞及少量的肺内间质.在实验组,VCAM-1亦表达于上述细胞并呈高表达,两者差异有统计学意义(P(0.05).结论:在博莱霉素致大鼠肺损伤中VCAM-1是肺血管损害的重要细胞因子之一,它参与了肺组织炎症和纤维化过程. AIM： To explore the expression of vascular cell adhesion molecule-1 （ VCAM-1 ） in pulmonary tissues of rats with bleomycin （BLM）-induced pulmonary fibrosis and the role of VCAM-1 in vascular injury. METHODS： The VCAM-1 in pulmonary tissues of rats with BLM-induced pulmonary fibrosis was analyzed by immunohistochemical technique and image processing system. RESULTS： The expression of VCAM-1 in the lung tissues of normal rats was weak, and distributed mainly in alveolar epithelial cells, bronchiole epithelial cells, alveolar macrophage and some pulmonary interstitium. The expression of VCAM-1 in lung tissues of rats with BLM -induced pulmonary fibrosis was higher than that in normal rats, with significant difference （P 〈 0.05 ）. CONCLUSION： VCAM-1 is one of the important cell factors in BLM-induced pulmonary fibrosis and it direcdy participates in the pulmonary inflammation and the process of fibrosis.
作者 陈利萍 刘华 贺永锋 朱新菊 李林 刘新社
机构地区 西安交通大学医学院法医系 北京市公安局 陕西省公安厅刑侦局 镇江市公安局刑侦支队
出处 《第四军医大学学报》 CAS 北大核心 2007年第6期537-539,共3页 Journal of the Fourth Military Medical University
基金 陕西省自然科学基金(2003C238) 北京市青年基金
关键词 血管细胞黏附分子-1 肺纤维化 血管/损伤 免疫组织化学 vascular cell adhesion molecule-1 pulmonary fibrosis blood vessels/injuries immunohistochemistry
分类号 R563.1 [医药卫生—呼吸系统]
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参考文献12

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共引文献33

同被引文献58

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引证文献6

二级引证文献20

第四军医大学学报
2007年 第6期

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