摘要
目的探讨依那普利联合科素亚治疗慢性肾小球肾炎尿蛋白的疗效。方法选择慢性肾小球肾炎60例,依那普利组(Ⅰ组)20例给予依那普利治疗;科素亚组(Ⅱ组)20例给予科素亚治疗;联合组(Ⅲ组)20例给予依那普利、科素亚联合治疗。3组疗程均为6个月,分别于治疗后评价疗效。结果跟踪治疗6月,Ⅲ组血压、24h尿蛋白均较Ⅰ、Ⅱ组明显下降(P<0.05),Ⅰ、Ⅱ组血压、24h尿蛋白水平亦下降,但不显著(P>0.05)。Ⅰ、Ⅱ、Ⅲ组血肌酐水平无明显变化。主要副作用是咳嗽、血钾轻度升高,但不影响治疗。结论依那普利组和科素亚组均有降低尿蛋白的作用,但两者联用降低尿蛋白的效果明显优于Ⅰ组、Ⅱ组。
Objective To evaluate the effect of Enalapril and losartan on patients with chronic glomerulonephritis （CGN）. Methods 60 patients with CGN were divided into three groups randomly： group Ⅰ , group Ⅱ and group Ⅲ. Enalapril and Losartan were both used in group Ⅲ patierts, Enalapril only were used in group Ⅰ patients, Losartan only were used in group Ⅱ patierts. All the treatment time were six months, and by the end of the treatment time, the efficiency were evaluated. Results By the end of the treatment, blood pressure and urine protein for 24 hours were detected in the three groups. There was significant difference between the group Ⅲ and the group Ⅰ （P 〈0.05）, and there was also significant difference between the group Ⅲ and the group Ⅱ （ P 〈 0.05 ）, but there was no difference between the group Ⅰ and the group Ⅱ （ P 〉 0.05 ）. As for the serum Creatinine （ Scr）, there were no changes in three groups. The primary side effect were cough and the increasing of the serum potassium level, both of them did no harm to the treatment. Conclusions Both Enalapril only and losartan only could decrease the urine protein, but when they were used together, the efficiency was much better than that when they were used respectively.
出处
《实用全科医学》
2007年第3期236-237,共2页
Applied Journal Of General Practice
