摘要
他汀类药物是目前临床上广泛使用的调脂药,近年来他汀类药物的非调脂作用日益引起人们的重视。动物实验发现,他汀类药物对缺血再灌注心肌有保护作用。大规模的临床试验也证实他汀类药物能有效减少冠脉事件的发生,并可以减少短期内冠脉事件再发的危险性,且长期应用受益更大。目前研究认为他汀类药物对缺血再灌注心肌的保护作用主要是通过改善内皮功能和抗炎作用实现的,也可通过动员内皮祖细胞、抗血栓、提高心肌能量及抗氧化损伤等机制有效的减轻缺血再灌注损伤。
Statins are a widely used cholesterol-lowering drug. The noncholesterol-lowering effects of statins have recently been recognised. Animal studies have shown statins could protect ischemic-reperfused myocardium. Large-scale clinical trials have shown that statins could reduce the incidence of coronary events and the short-term risk of recurrence after the coronary events. Long-term treatment with statins has wider effects. The major mechanisms of protecting ischemic-reperfused myocardium are improving endothelial function and anti-inflammatory effect. In addition, statins alleviate ischemical reperfusion injury by mobilizing endothelial progenitor cells, preventing thrombosis, improving ATP level and antioxidation.
出处
《心血管病学进展》
CAS
2007年第2期229-232,共4页
Advances in Cardiovascular Diseases
