摘要
对狼疮倾向ＮＺＢ／ＷＦ１小鼠在４月龄时腹腔注射抗鼠ＩＬ－１α、抗ＩＬ－６单抗，每日１次１０μｇ×３ｄ，后每月１次×３次，１１月龄活杀，发现这样的剂量不能完全防治狼疮性肾炎，但可减轻蛋白尿，明显降低血清ＩＬ－１α水平，抑制腹腔巨噬细胞分泌ＩＬ－１α。对ＩＬ－６和ＴＮＦ－α水平无明显影响。
μg of anti-murine IL-1α、IL-6 monoclonal antibodies were intraperitonealy injected to the lupus-like NZB/W F1 mice of 4 months every day for three days and then every month for three months. The mice were killed at the age of 11 months. Experimental results showed that this dosage could not absolutely prevent lupus glomerulonephritis, it could lighten proteinuria, obviously reduce the level of serum IL-1α and inhibit the secretion of IL-1α by celiac macrophage. As to the level of IL-6 and TNF-α, no significant change was observed.
出处
《上海免疫学杂志》
CSCD
北大核心
1996年第5期270-272,共3页
Shanghai Journal of Immunology
基金
国家自然科学基金
湖北省自然科学基金
