摘要
目的观察乙型肝炎病毒e抗原(HBeAg)阴性慢性乙型肝炎(CHB)患者的肝组织病理分级、分期及其与丙氨酸氨基转移酶(ALT)的关系。方法收集我院HBeAg阴性CHB406例肝穿病理标本,常规HE、Masson三重染色,光镜下观察其病理变化并进行分级和分期,并比较其与ALT的关系。结果病理诊断为HBeAg阴性CHB轻度292例(71.92%),中度96例(23.65%),重度18例(4.43%)。其中73.65%的患者肝脏炎症损伤≥G2,64%患者已出现不同程度的肝纤维化。炎症活动度分级与ALT分级比较差异无显著性(P=0.367)。结论70%的HBeAg阴性CHB患者存在不同程度肝脏炎症损伤和(或)肝纤维化,且与ALT的增高程度没有相关性,约30%的患者肝脏炎症损伤和纤维化程度较重。
Objective To analyse the clinical and pathological features in chronic hepatitis B （CHB） with negative hepatitis B e antigen （HBeAg）. Methods 406 pathological samplesin CHB with negative HBeAg were included. Pathological changes were observed after using HE and Masson triple dye. Then the grade and stage of these samples were identified. The association between Alanine aminotransferase （ALT） and pathological grade or stage was compared. Results The results of pathological diagnosis showed that there were 292 （ 71.92% ） CHB patients with mild 96 （ 23.65 % ） with moderate, and 18 （4.33%） with severe pathological changes. 73.65% CHB patients with negative HBeAg had liver inflammation injury ≥G2 and various degree of liver fibrosis. The differences between the grades of inflammatory activity and ALT level had no significance. （P = 0.367）. Conclusion Most of CHB patients with negative HBeAg had various degree of liver inflammation or fibrosis, and there was no relationship withthe increasing value of ALT,while 30% of these patients had severe degree, of liver inflammation or fibrosis.
出处
《临床内科杂志》
CAS
2007年第2期94-95,共2页
Journal of Clinical Internal Medicine
