摘要
目的:研究血塞通滴丸抗血栓、溶栓作用,并从该药对血液流变性的影响初步分析其作用机制。方法:大鼠随机分为5组,空白对照组,血塞通滴丸90,30,10 mg.kg-13个剂量组,血塞通片30 mg.kg-1组,运用动静脉环路法测定血塞通滴丸对大鼠旁路血栓形成的影响;大鼠随机分为7组,模型组,血塞通滴丸90,30,10 mg.kg-13个剂量组,血塞通片90,30 mg.kg-1组,蚓激酶胶囊组,以颈总动脉温度测定法测定血塞通滴丸对大鼠总动脉血栓形成后的溶栓作用;大鼠随机分为6组,空白对照组,模型组,血塞通滴丸80,40 mg.kg-12个剂量组,血塞通片40,20 mg.kg-12个剂量组,以急性应激大鼠模型观察血塞通滴丸对其血液流变学的影响。结果:血塞通滴丸90,30 mg.kg-1可使血栓湿重和干重明显下降(P<0.01),且剂量之间显示出一定的量-效关系。血塞通滴丸90mg.kg-1有明确的溶栓作用(P<0.01)。血塞通滴丸80,40,20 mg.kg-1对红细胞聚集性有明显的降低作用(P<0.01),对低切全血黏度有一定的降低作用(P<0.05)。80,40 mg.kg-1血塞通滴丸分别对中切黏度和血浆黏度有一定的降低作用(P<0.05)。80 mg.kg-1血塞通滴丸分别对高切黏度有一定的降低作用(P<0.05)。结论:血塞通滴丸具有较好的抗血栓与溶栓作用,其对血液流变性的影响是抗血栓与溶栓的作用机制之一。
Objective： To study the effect and the mechanism of Xuesaitong drop pills （total sapenins in Radix Notoginseng; XDP） on experimental thrombosis, thrombolysis and blood theology. Method： First, the rats were randomly divided into five groups： control, XDP （90, 30, 10 mg·kg^-1 ）, Xuesaitong tablet （XP） 30 mg·kg^-1. Then the effect of the drugs on thrombus and thrombosis was studied after the ratsthrombosis was induced by the arteriovenous shunt. Second, the rats were randomly divided into seven groups： model, XDP （90, 30, 10 mg·kg^-1 ）, XT （90, 30 mg·kg^-1 ）, lumbrukinase capsule. Then the effect of the drugs on thrombus and thrombosis was studied after the rats＇thrombosis was induced by the electrical stimulation of common carotid artery. Third, the rats were randomly divided into six groups： control, model, XDP （80, 40 mg·kg^-1 ）, XT （40, 20 mg·kg^-1）. Then the effect of the drugs on blood circulation promoting was observed after the rats＇acute blood stasis induced by adrenalin and icy water. Result： XDP 90, 30 mg·kg^-1 could notably lighten the wet-weight and dry-weight of thrombus in the arteriovenous shunt model in rats in a dose-dependent manner （P 〈0.01）. XDP 90 mg·kg^-1 with intragastric administration for 3 days had the satisfactory effect on thrombolysis after the rats thrombosis was induced by the electrical stimulation of common carotid artery （P 〈0.01 ）. XDP 80 , 40 , 20 mg·kg^-1 reduced significantly erythrocyte aggregation （P 〈0.01 ） and decreased the whole blood viscosity at low shear rate （P 〈 0.05）. XDP 80, 40 mg·kg^-1 reduced the whole blood viscosity at high shear rate and plasma viscosity （P 〈 0.05）. XDP 80 mg·kg^-1 decreased the whole blood viscosity at high shear rate （P 〈 0.05）. Conclusion： XDP can significantly inhibit the thrombosis and has the satisfactory effect on thrombolysis. One kind of the mechanism is related to the effect on blood rheology.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2007年第3期253-256,共4页
China Journal of Chinese Materia Medica
关键词
血塞通滴丸
抗血栓
溶栓
Xuesaitong drop pills
thrombosis
thrombolysis
