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Survivin蛋白表达与卵巢恶性生殖细胞肿瘤临床病理特征的关系

Survivin Expression in Ovarian Germ Cell Tumors
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摘要 目的探讨Survivin蛋白表达与卵巢恶性生殖细胞肿瘤发生发展的关系。方法采用免疫组化链菌素亲生物素蛋白-过氧化酶连接法(labelled streptavidin biotin method,LSAB)检测10例正常卵巢和29例卵巢恶性生殖细胞肿瘤组织石蜡标本中Survivin蛋白的表达状况。结果正常卵巢组织中无Survivin蛋白的表达;Sur-vivin蛋白表达定位在肿瘤细胞的胞浆和胞核中;卵巢恶性生殖细胞肿瘤中Survivin蛋白表达阳性率为58.6%,高于正常卵巢组织(P<0.05),但Survivin蛋白表达与恶性生殖细胞肿瘤的病理类型、FIGO分期、淋巴结转移、血清AFP含量及腹水量间均无明显关联(P>0.05)。结论Survivin蛋白表达水平增高可能与卵巢恶性生殖细胞的发生有关。 Objective To investigate the relationship between the expression of survivin and the development of ovarian germ cell tumors （OGCT）. Methods Survivin expressions in normal ovaries （n=10）and ovarian germ cell tumors （n=29） were detected with labelled streptavidin biotin method. Results No survivin protein was expressed in normal ovaries. Survivin protein was found in the cytoplasm and/or the nuclear of cells of 58. 6%（17/29） of the ovarian germ cell tumor samples （P〈0. 05）. There was no significant correlations between surviving protein and the pathologic types, stage, lymphonode metastasis,AFP and volume of ascites of the tumors （P〉0. 05）. Conclusion High expression of survivin protein may trigger the pathogenesis of the ovarian germ cell tumors.
作者 尹如铁 彭芝兰 杨开选 康德英
机构地区 四川大学华西第二医院妇产科 四川大学华西医院临床流行病教研室
出处 《四川大学学报（医学版）》 CAS CSCD 北大核心 2007年第2期243-245,共3页 Journal of Sichuan University(Medical Sciences)
基金 四川省科技厅重点项目(04SG022-016-06)资助
关键词 SURVIVIN蛋白 卵巢恶性生殖细胞肿瘤 Survivin Ovarian germ cell tumors
分类号 R737.31 [医药卫生—肿瘤]
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参考文献15

  • 1Skoufias DA,Mollinari C,Lacroix FB,et al.Human survivin is a kinetochore-associated passenger protein.J cell Bio,2000;151(7):1575-1581.
  • 2Zhou MX,Gu LB,Li FZ,et al.DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic cells.J Pharmacol Exp Ther,2002;303(1):124-131.
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二级参考文献17

  • 1Nakano J, Huang CL, Liu D, et al. Survivin gene expression is negatively regulated by the p53 tumor suppressor gene in non-small cell lung cancer. Int J Oncol,2005;27(5):1215-1219.
  • 2Sui L, Dong Y, Ohno M, et al. Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovanian tumors .Int J oncol, 2002;21(2):315-320.
  • 3Yoshida H, Ishiko O, Sumi T, et al. Survivin,bcl-2 and matrix metalloproteinase-2 enhance progression of clear cell and serous-type ovarian carcinomas. Int J Oncol,2001;19:527-542.
  • 4Takai N, Miyazaki T, Nishida M, et al. Expression of survivin is associated with malignant potentical in epithelial ovarian carcinoma. Int J Mol Med, 2002;10(2):211-216.
  • 5Hattori M, Sakamoto H, Satoh K, et al. DNA demethylase is expressed in ovarian carcers and the expression correlates with demethylation of CpG sistes in the promoter region of C-erbB-2 and survivin genes.Cancer Lett,2001;169(2):155-164.
  • 6Ambrosini G, Adida C, Altieri DC, et al. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med,1997;3(8):917-921.
  • 7Skoufias DA, Mollinari C, Lacroix FB,et al. Human survivin is a kinetochore-associated passenger protein. J Cell Bio, 2000;151(7):1575-1581.
  • 8Zhou MX, Gu LB, Li FZ, et al. DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic cells. J Pharmacol Exp Ther,2002;303(1):124-131.
  • 9Zaman GJR,Conway EM. The elusive factor Xa receptor:failure to detect transcripts that correspond to the published sequence of EPR-1 Hemostasis, Blood,2000;96(1):145-148.
  • 10Sugawara M, Matsuzhka F, Fukata S, et al. Excessive survivin expression in thyroid lymphomas. Hum Pathol,2002;33:524-527.

共引文献27

四川大学学报（医学版）
2007年 第2期

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