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糖尿病大鼠胰岛中激素敏感性脂肪酶表达和活性的变化 被引量：4

Expression and activity of hormone sensitive lipase in islets of diabetic rats
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摘要 观察糖尿病大鼠胰岛中激素敏感性脂肪酶（HsL）和甘油三酯（TG）的变化，发现高脂饮食的糖尿病大鼠胰岛内脂质含量、HSL的表达和活性明显高于正常对照组（均P〈0．05），降低血糖不仅减少胰岛中TG的含量，而且HSL的表达和活性也下降。 The changes of expression and activity of hormone sensitive lipase （HSL） and triglyceride （TG） in the islets of diabetic rats were markedly increased as compared with normal control group （ all P 〈 0. 05 ）. Normalization of blood glucose reduced both content of TG and the expression and activity of HSL in the islet.
作者 王咏波 陈璐璐 周慜 王保平
机构地区 华中科技大学同济医学院附属协和医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2007年第1期35-36,共2页 Chinese Journal of Endocrinology and Metabolism
基金 湖北省自然基金（2003ABA143）
关键词 胰岛 激素敏感性脂肪酶 甘油三酯 Islet of Langerhans Hormone sensitive lipase Tfiglycefide
分类号 R686 [医药卫生—骨科学]
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共引文献38

同被引文献31

  • 1孙长颢,刘荣,李颖,王舒然.饮食诱导肥胖抵抗大鼠激素敏感脂肪酶基因的表达[J].中华预防医学杂志,2004,38(5):339-341. 被引量：9
  • 2黄青阳,程孟荣,姬森林.2型糖尿病易感基因的连锁和关联研究(英文)[J].Acta Genetica Sinica,2006,33(7):573-589. 被引量：20
  • 3麻微微,赵丹,苏畅,王舒然,蔺威鸣,王国秀.饮食诱导肥胖易感和肥胖抵抗大鼠HSL和LPL基因表达的研究[J].卫生研究,2007,36(3):320-322. 被引量：12
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  • 10Winzell MS,Holm C,Ahren B.Downregulation of islet hormonesensitive lipase during long-term high-fat feeding.Biochem Biophys Res Commun,2003,304:273-278.

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中华内分泌代谢杂志
2007年 第1期

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