摘要
背景与目的:近距离放疗的空间剂量分布和外照射明显不同,两者联合使用可以优势互补,提高剂量分布的适形度。本研究旨在探讨Ⅰ、Ⅱ期鼻咽癌患者采用单纯外照射放疗与外照射加腔内联合放疗的长期疗效差异。方法:将321例Ⅰ、Ⅱ期鼻咽癌患者,随机分为单纯外照射组223例,外照射加腔内联合放疗组98例;单纯外照射组采用低熔点铅挡块不规则野照射,常规方法照射,常规分割,总剂量为66～74Gy;联合放疗组采用同样的外照射方法,总剂量给与58～62Gy,接着给予15～20Gy腔内近距离放疗。结果:经过5年的随访,单纯外照射组鼻咽复发16例,死亡35例,Ⅰ、Ⅱ期鼻咽癌患者的5年生存率分别为90.63%和80.82%(P=0.018);联合照射组鼻咽复发1例,死亡6例,Ⅰ、Ⅱ期鼻咽癌的5年生存率分别为95.24%和93.36%(P=0.025)。口干和张口困难的不良反应以联合照射组较轻。结论:Ⅰ、Ⅱ期鼻咽癌患者采用外照射加腔内放疗相对单纯外照射有较好的疗效并可减轻不良反应。
BACKGROUND ＆ OBJECTIVE： The dose distribution of brachytherapy is different from that of external radiotherapy. Combining these 2 modolities can enhance the conform degree of dose distribution. This study was to evaluate long-term efficacy of external plus intracavitary irradiation on stage Ⅰ- Ⅱ nasopharyngeal carcinoma （NPC）. METHODS： A total of 321 patients were randomized into 2 groups, 223 in simplex group were given conventional irradiation in total doses of 66-74 Gy with lead block fitful fields; 98 in combination group were given the same external irradiation in total doses of 58-62 Gy and 15-20 Gy intracavitary irradiation. RESULTS： Within 5- year follow-up, in simplex group, 16 patients had tumor relapsed at the nasopharynx and 35 died, with 5-year overall survival rates of 90.63% for stage Ⅰ patients and 80.82% for stage Ⅱ patients （P=0.018）;in combination group, 1 patient had tumor relapsed at the nasophaynx and 6 died, with 5- year overall survival rates of 95.24% for stage I patients and 93.36% for stage Ⅱ patients （P=0.025）. There were fewer adverse events in combination group. CONCLUSION： The long-term efficacy of external plus intracavitary radiotherapy on stage Ⅰ- Ⅱ NPC is better than that of conventional external radiotherapy alone with fewer adverse events.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2007年第2期204-207,共4页
Chinese Journal of Cancer
关键词
鼻咽肿瘤/放射疗法
近距离放疗
疗效
不良反应
Nasopharyngeal neoplasm/radiotherapy
Brachytherapy
Treatment effectiveness ； Adverse event
