摘要
本文采用测痛和免疫组织化学法，观察到大鼠鞘内注射（it）P物质（SP）所引起痛反应与剂量有关，小剂量（0．5μg，1μg）对痛阈无明显影响，大剂量（5μg，10μg）可使之降低，并可诱发脊髓c－fos的表达。it吗啡（10μg）不仅使痛阈提高，还可抑制itSP产生的痛反应及脊髓C－fos表达，此效应可被纳洛酮翻转。
Using pain measurement and immunohistochemistry, we have observed that the intrathecal injection (it) SP produced dose-related pain response. A larger dose of SP (5μg, 1eμg) could reduce the pain thresho1d and evoke c-fos expression, but no obvious effect was produced by a smaller dose of SP (0. 5μg, 1μg). Morphine (it) not only increased the pain threshold, but also inhibited pain response and c-fos expression of spinal cord induced by it SP, the effects could be reversed by naloxone
出处
《针刺研究》
CAS
CSCD
1996年第1期65-69,共5页
Acupuncture Research
