摘要
目的:探讨药物分子槲皮素、芦丁的小肠吸收情况。方法:利用Caco-2细胞模型观察药物分子由细胞绒毛面(A面)到基底面(B面)、基底面(B面)到细胞绒毛面(A面)两个方向的转运过程。结果:由细胞绒毛面(A面)到基底面(B面)槲皮素的表观渗透系数(Papp)=(5.15±0.65)×10-6cm.s-1,芦丁的Papp=(0.05±0.01)×10-6cm.s-1,由基底面(B面)到细胞绒毛面(A面)槲皮素及芦丁的Papp分别为(10.54±1.35)×10-6cm.s-1和(0.07±0.01)×10-6cm.s-1。结论:槲皮素、芦丁可以通过小肠上皮细胞吸收进入体内,槲皮素较芦丁更易于吸收。
Objective To study the absorption of quereetin and rutin in human intestinal epithelial. Methods By using Caeo-2 cell line as an intestinal epithelial cell model, the transportatrions of quercetin and rutin were studied from apical side to basolateral side or from basolateral side to apical side. Results The apparent permeabilities （Papp） of quereetin and rutin from the apical side to basolateral side were （ 5. 15±0.65）×10^-6cm·s^-1 and （0. 05±0.01）×10^-6cm·s^-1, respectively. The Papp of quercetin and rutin from basolateral side to apical side were （10.54±1.35）×10^-6cm·s^-1 and （0.07±0.01）×10^-6cm·s^-1, respectively. Conclusion Quercetin and rutin can be absorbed across intestinal epithelial cells, moreover qereetin is easier to be absorbed than rutin.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2007年第1期33-36,共4页
Journal of Jilin University：Medicine Edition
基金
国家自然科学基金资助课题(30371757)
