摘要
设计了新的头孢噻呋钠的合成路线:7-氨基头孢烷酸(7-ACA)先与呋喃-2-甲硫羟酸缩合,再与AE-活性酯反应,后与异辛酸钠反应得到头孢噻呋钠。以7-ACA计算,反应总收率为39.9%。改进的新工艺反应步骤缩短。
This article designed a new synthetic route of ceftiofur sodium. The condensation product of 7-ACA and furan-2-thiol-formic acid reacted with AE thiolester, and then treated with sodium-2-ethyl hexanoate ,At last ,ceftiofur sodium was prepared. If caculated by 7-ACA, the total yield rate of ceftiofur sodium was 39.9%. The new method shortened the process.
出处
《中国兽药杂志》
2007年第2期19-20,共2页
Chinese Journal of Veterinary Drug
