摘要
目的探讨影响根治性胃癌切除术后患者生存率的有效预后指标。方法对183例行根治性胃癌切除术后患者的年龄、性别、肿瘤部位、组织学类型、生长方式、PTNM分期,nm23-H1蛋白表达、p16蛋白表达、胃切除范围和手术根治度进行单因素分析，并将单因素分析有统计学意义的指标引入COX模型行多因素回归分析。结果单因素分析显示肿瘤部位、组织学类型、生长方式、PTNM分期、nm23-H1蛋白表达、p16蛋白表达和手术根治度与胃癌根治性切除术后1、3、5年生存率显著相关。COX多因素回归分析表明PTNM分期、p16蛋白表达、生长方式和组织学类型是影响胃癌根治性切除术后患者生存率的独立的预后因素。结论PTNM分期、p16蛋白表达、肿瘤生长方式和组织学类型可作为判断胃癌根治性切除术术后患者的独立预后因素。
Objective To determine the effective prognostic parameters of long-term survival tor gastric cancer after radical resection. Method The prognostic relevance of clinical and pathological variables（including the expression of nm23-H1 and p16 protein） in 183 patients who had underwent radical resection for gastric cancer were evaluated by the univariate and COX multivariate regression analysis. Results The tumor location, histology, growth pattern, PTNM stages, the expression of nm23-H1 and p16 protein, the degree of radical resection were significantly correlated with tbe overall 1-, 3- and 5- year survival rates by univariate analysis. With these parameters entering the COX multivariate regression analysis model, it is revealed that PTNM stages, the expression of p16 protein, histology and Ming＇s tumor growth pattern were significant prognostic factors for 1-, 3- and 5- year survival rates. Conclusions PTNM stages, the expression of p16 pro- tein, histology and Ming＇s tumor growth pattern are the most important and best parameters in predicting the clinical outcome of gastric cancer after radical resection.
出处
《肿瘤研究与临床》
CAS
2007年第1期37-39,共3页
Cancer Research and Clinic
关键词
胃肿瘤
胃切除术
预后
回归分析
Stomach neoplasm
Gastrectomy
Prognosis
Regression analysis
