摘要
目的:探讨硫酸镁和复方丹参联合应用对新生儿窒息(NA)心肌损伤的治疗作用及安全性。方法:NA合并心肌损伤患儿24例,随机分为对照组和治疗组各12例。对照组应用1,6-二磷酸果糖(FDP)治疗,剂量250mg.kg-1,静脉点滴连用7天。治疗组应用硫酸镁和复方丹参治疗:硫酸镁剂量200mg.kg-130 m in静脉滴注,继以10 mg.kg-1.h-1维持量用微量输液泵持续泵入,连用5天;复方丹参1 m l.kg-1静脉点滴,疗程7天。观察心肌钙蛋白I(cTnI)、肌酸激酶心肌同工酶(CK-MB)、肌酸激酶(CK)等指标的变化。结果:(1)治疗前治疗组和对照组cTnI分别为(1.83±2.01)ng.m l-1和(1.78±1.86)ng.m l-1;治疗后分别为(0.06±0.02)ng.m l-1和(0.15±0.11)ng.m l-1治疗后两组相比结果有显著性差异(P<0.05)。(2)治疗前治疗组和对照组CK-MB分别为(69.3±30.2)IU.L-1和(61.7±38.5)IU.L-1;治疗后两组分别为(31.3±12.5)IU.L-1和(43.2±16.8)IU.L-1,均较治疗前明显降低(P<0.05)。(3)治疗前治疗组和对照组CK分别为(968.3±580.2)IU.L-1和(897.5±502.7)IU.L-1;治疗后两组分别为(210.4±178.3)IU.L-1和(357.3±190.2)IU.L-1,与治疗前相比均有显著差异(P<0.05)。结论:硫酸镁和复方丹参对NA心肌损伤有明确治疗作用,无不良反应。
Objective： To investigate the therapeutic effect and safety of magnesium sulfate and salvia mihiorrhiza injection on neonatal asphyxia （NA） with myocardial injury. Methods： Twenty -four myocardial injury newborns were randomized into two groups, with 12 cases each. The control group was given Fructose- 1,6- diphosphate （FDP） 250mg·kg^-1 intravenously for 7 days. The treatment group was given magnesium sulfate （200mg·kg^-1 intravenously within 30 minutes）, followed by maintenance infusion （10mg·kg^-1 hourly） for 5 days and salvia mihiorrhiza injection （ 1ml·kg^-1 ） for 7 days. All the cases were finished basing on supportive and symptomatic therapy. The cardiac troponin Ⅰ（cTnⅠ）, creatin kinase_ _ MB （CKMB）, creatin kinase （CK） were recorded before and after the treatment for comparison. Results： （ 1 ） The cTnI in the treatment and control groups before treatment was respectively 1.83±2. 01 ng·m^-1 and 1.78±1.86 ng·ml^-1. There was significant difference between the treatment group （0. 06±0. 02ng·ml^-1） and the control group （0. 15±0.11ng·ml^-1 ） after treatment. （P 〈 0. 05） . （2） The CK - MB in the treatment and control groups before treatment was respectively 69. 3±30. 2IU·L^-1 and 61.7±38.5 IU·L^-1 （P〉0.05）, and respectively 31.3±12.5 IU·L^-1 and 43.2±16.8 IU·L^-1 （P 〉0.05） after treatment, both with marked decrease compared with those before treatment （P 〈 0. 05 ） . （3） The CK in the treatment and control groups before treatment was respectively 968. 3±580. 2IU·L^-1 and 897. 5±502. 7 IU·L^-1 （P 〉0. 05）, and respectively 210. 4±178. 3 IU·L^-1 and 357. 3±190. 2 IU·L^-1 （P 〉 0. 05 ） after treatment. Both had marked difference before and after the treatment （P 〈 0. 05 ） . Conclusion： The combined therapy of magnesium sulfate and salvia miltiorrhiza injection has definite therapeutic effect on myocardial injury in NA without any obvious adverse reaction.
出处
《中国妇幼保健》
CAS
北大核心
2007年第2期223-225,共3页
Maternal and Child Health Care of China
关键词
新生儿窒息
心肌损伤
硫酸镁
复方丹参
心肌钙蛋白Ⅰ
Neonatal asphyxia
Myocardial injury
Magnesium sulfate
Salvia mihiorrhiza injection
Cardiac troponin Ⅰ
