摘要
目的 评价海藻酸钠微球（KMG）行部分性脾栓塞术（PSE）治疗肝癌并脾功能亢进（脾亢）的疗效及并发症。资料与方法 58例肝癌并脾亢行PSE患者，依据PSE术所采用的栓塞材料不同分为2组：A组30例，栓塞材料为明胶海绵颗粒；B组28例，栓塞材料为KMG。随访观察两组外周血自细胞（WBC）、血小板（PLT）和红细胞（RBC）计数变化及术后反应。结果 两组患者术后1周、2周、1个月、6个月的WBC和PLT计数均较术前明显升高（P〈0．001）。虽然B组术后WBC和PLT计数较A组升高较多，但两组的疗效差异无统计学意义（P〉0．05）。两组术后RBC计数一直无明显变化（P〉0．05）。随着栓塞程度的增加，外周血WBC和PLT计数升高越明显，但是术后反应加重．并发症也随之增加。结论 KMG可作为PSE术的栓塞材料，将栓塞程度控制在50％～60％可有效治疗脾亢，减轻术后反应。
Objective To evaluate the efficacy and complications of partial splenic embolization（PSE） using KMG for patients with liver cancer and hypersplenism. Materials and Methods 58 patients with liver cancer and hypersplenism were treated with PSE. According to the difference of the embolie material in PSE,58 patients were divided into 2 groups. Group A：30 patients with gelfoam cubes as the embolic material of PSE. Group B ： 28 patients with KMG as the embolic material of PSE. The ibllow up indices included peripheral blood cells counts （white blood cell （WBC）, platelet （PLT） and red blood cell （RBC）） and the complications associated with PSE. Results In group A and group B, WBC and PLT counts increased significantly higher than that on pre-embolization from 1 - 2 weeks to 6 months after PSE （P 〈 0.001 ）. Although WBC and PLT counts reached higher level after PSE in group B than that in group A, but had not perceivable difference in postoperation efficacy （P 〉 0.05）. RBC counts did not show significant changes after PSE within 6 months follow-up （ 19 〉 0.05）. The increment of embolization degree could induce the increment of the WBC and PLT counts, which aggravated post-embolization syndrome and increased the incidence of complications. Conclusion KMG may be used as the embolic material of PSE with embolization degree ranging from 50% to 60% which may alleviate hypersplenism in patients with liver cancer, and also decrease the incidence of post-embolization complications.
出处
《临床放射学杂志》
CSCD
北大核心
2007年第1期53-56,共4页
Journal of Clinical Radiology
关键词
脾功能亢进
肝癌
栓塞
海藻酸钠微球
治疗性
Hypersplenism Liver cancer Embolization Sodium algina, therapeutic
